Computational modeling reveals inflammation-driven dilatation of the pulmonary autograft in aortic position

Maes, Lauranne; Vervenne, Thibault; Hoof, Lucas Van; Jones, Elizabeth A. V.; Rega, Filip; Famaey, Nele

doi:10.1007/s10237-023-01694-6

Cited by 5 publications

(2 citation statements)

References 43 publications

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“…We have previously demonstrated that the absence of inflammation in the model can overcome this mismatch. The inclusion of an additional inflammation-related remodeling term after surgery could additionally predict that fast diameter increase too [20].…”

Section: Hypothesis 2: Gandr Driven By Pulsatile Stressesmentioning

confidence: 99%

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Drivers of Vascular Growth and Remodeling: A Computational Framework to Promote Benign Adaptation in the Ross Procedure

Vervenne,

Maes,

Van Hoof

et al. 2023

Preprint

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Section: Hypothesis 2: Gandr Driven By Pulsatile Stressesmentioning

confidence: 99%

“…Computational models have already been used to investigate the long-term outcomes of a pulmonary autograft [18,19,20]. On the other hand, simulations have shown that both an external support and gradual loading can promote benign adaptation in vascular growth and remodeling (G&R) [21,22].…”

Section: Introductionmentioning

confidence: 99%

Drivers of Vascular Growth and Remodeling: A Computational Framework to Promote Benign Adaptation in the Ross Procedure

Vervenne,

Maes,

Van Hoof

et al. 2023

Preprint

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Foreword to the special issue entitled “Progress and future directions in soft tissue mechanics” in the Journal Biomechanics and Modeling in Mechanobiology

Avril,

Holzapfel

2023

Biomech Model Mechanobiol

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Growth and remodeling of the dissected membrane in an idealized dissected aorta model

Gheysen,

Maes,

Famaey

et al. 2023

Biomech Model Mechanobiol

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While transitioning from the acute to chronic phase, the wall of a dissected aorta often expands in diameter and adaptations in thickness and microstructure take place in the dissected membrane. Including the mechanisms, leading to these changes, in a computational model is expected to improve the accuracy of predictions of the long-term complications and optimal treatment timing of dissection patients. An idealized dissected wall was modeled to represent the elastin and collagen production and/or degradation imposed by stress- and inflammation-mediated growth and remodeling, using the homogenized constrained mixture theory. As no optimal growth and remodeling parameters have been defined for aortic dissections, a Latin hypercube sampling with 1000 parameter combinations was assessed for four inflammation patterns, with a varying spatial extent (full/local) and temporal evolution (permanent/transient). The dissected membrane thickening and microstructure was considered together with the diameter expansion over a period of 90 days. The highest success rate was found for the transient inflammation patterns, with about 15% of the samples leading to converged solutions after 90 days. Clinically observed thickening rates were found for 2–4% of the transient inflammation samples, which represented median total diameter expansion rates of about 5 mm/year. The dissected membrane microstructure showed an elastin decrease and, in most cases, a collagen increase. In conclusion, the model with the transient inflammation pattern allowed the reproduction of clinically observed dissected membrane thickening rates, diameter expansion rates and adaptations in microstructure, thus providing guidance in reducing the parameter space in growth and remodeling models of aortic dissections.

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Computational modeling reveals inflammation-driven dilatation of the pulmonary autograft in aortic position

Cited by 5 publications

References 43 publications

Drivers of Vascular Growth and Remodeling: A Computational Framework to Promote Benign Adaptation in the Ross Procedure

Drivers of Vascular Growth and Remodeling: A Computational Framework to Promote Benign Adaptation in the Ross Procedure

Foreword to the special issue entitled “Progress and future directions in soft tissue mechanics” in the Journal Biomechanics and Modeling in Mechanobiology

Growth and remodeling of the dissected membrane in an idealized dissected aorta model

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