Computational Modeling of Cyclic Nucleotide Signaling Mechanisms in Cardiac Myocytes

Zhao, Claire Y.

doi:10.1007/978-3-319-54579-0_10

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Compartmentation Of Camp and Cgmp Signaling1

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2018

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“…Among the relevant experimental evidence, studies on knockout mice do also highlight the importance of the crucial role PDEs play in the cAMP/cGMP signaling pathways and their respective crosstalk [ 76 ]. The interplay among the β-adrenergic and NO/cGMP/PKG pathways can be interpreted as a network phenomenon arising from the molecular selectivity of PDEs to cAMP and cGMP [ 77 ].…”

Section: Compartmentation Of Camp and Cgmp Signalingmentioning

confidence: 99%

Imaging of PDE2- and PDE3-Mediated cGMP-to-cAMP Cross-Talk in Cardiomyocytes

Pavlaki

Nikolaev

2018

JCDD

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Cyclic nucleotides 3′,5′-cyclic adenosine monophosphate (cAMP) and 3′,5′-cyclic guanosine monophosphate (cGMP) are important second messengers that regulate cardiovascular function and disease by acting in discrete subcellular microdomains. Signaling compartmentation at these locations is often regulated by phosphodiesterases (PDEs). Some PDEs are also involved in the cross-talk between the two second messengers. The purpose of this review is to summarize and highlight recent findings about the role of PDE2 and PDE3 in cardiomyocyte cyclic nucleotide compartmentation and visualization of this process using live cell imaging techniques.

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Section: Compartmentation Of Camp and Cgmp Signalingmentioning

confidence: 99%