Computational modeling of cell mechanics

Experimental and numerical responses of fibroblast and epithelial cells to the frequency of electric toothbrush

“…Various biological processes, particularly phenotypic modi cation, are employed by cells in response to these forces. Different models, including viscous, elastic, and viscoelastic, can be used to simulate the cell response as cell stiffness (Liebman et al 2020) (Rodriguez and Sniadecki 2014). Recent advances in measuring cell mechanics have revealed that alterations in cell mechanical activity disclose manifestations of numerous human diseases, particularly cancer (Heydarian et al 2020).…”

A genetic algorithm-based method for the mechanical characterization of biosamples using a MEMS microgripper: numerical simulations

“…Mechanical cues or abnormal environments can disturb their normal function, and disease states can arise. Asthma, osteoporosis, deafness, atherosclerosis, cancer, osteoarthritis, glaucoma, muscular dystrophy, and pressure ulcers can be directly caused by or catalyzed by irregular cell mechanics (Rodriguez et al, 2013;Rodriguez and Sniadecki, 2014;Ingber, 2003). Therefore, mechanical characterization of single cells can provide useful information about these processes.…”