2021 43rd Annual International Conference of the IEEE Engineering in Medicine &Amp; Biology Society (EMBC) 2021

DOI: 10.1109/embc46164.2021.9630376

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Computational modeling of atherosclerotic plaque progression in carotid lesions with moderate degree of stenosis

Michalis D. Mantzaris¹,

Panagiotis K. Siogkas²,

Vassilis Tsakanikas³

et al.

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Introduction2

Methods1

Modeling Hemodynamics During Atherosclerotic Initiation and ...1

Pogled U Budućnost: Stratifikacija Pacijenata Sa Karotidnom ...1

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Cited by 8 publications

(6 citation statements)

References 13 publications

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“…The proposed platform has been developed based on the data collected during the clinical study of the TAXINOMIS project [6], [7]. This data has been used to build the relative models and validate them through a set of studies [8], [9], [10], [11], [12], [13], [14], [15].…”

Section: Methodsmentioning

confidence: 99%

TAXINOMISIS: A cloud – based platform for risk profiling and patient specific management of the carotid artery disease

Tsakanikas,

Siogkas,

Potsika

et al. 2023

2023 45th Annual International Conference of the IEEE Engineering in Medicine &Amp; Biology Society (EMBC)

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Carotid Artery Disease is a complex multidisciplinary medical condition causing strokes and several other disfunctions to individuals. Within this work, a cloudbased platform is proposed for clinicians and medical doctors that provides a comprehensive risk assessment tool for carotid artery disease. It includes three modeling levels: baseline datadriven risk assessment, blood flow simulations and plaque progression modeling. The proposed models, which have been validated through a wide set of studies within the TAXINOMISIS project, are delivered to the end users through an easy-to-use cloud platform. The architecture and the deployment of this platform includes interfaces for handling the electronic patient record, the 3D arterial reconstruction, blood flow simulations and risk assessment reporting. TAXINOMISIS, compared with both similar software approaches and with the current clinical workflow, assists clinicians to treat patients more effectively and more accurately by providing innovative and validated tools.

“…The proposed platform has been developed based on the data collected during the clinical study of the TAXINOMIS project [6], [7]. This data has been used to build the relative models and validate them through a set of studies [8], [9], [10], [11], [12], [13], [14], [15].…”

Section: Methodsmentioning

confidence: 99%

TAXINOMISIS: A cloud – based platform for risk profiling and patient specific management of the carotid artery disease

Tsakanikas,

Siogkas,

Potsika

et al. 2023

2023 45th Annual International Conference of the IEEE Engineering in Medicine &Amp; Biology Society (EMBC)

Self Cite

View full text Add to dashboard Cite

Carotid Artery Disease is a complex multidisciplinary medical condition causing strokes and several other disfunctions to individuals. Within this work, a cloudbased platform is proposed for clinicians and medical doctors that provides a comprehensive risk assessment tool for carotid artery disease. It includes three modeling levels: baseline datadriven risk assessment, blood flow simulations and plaque progression modeling. The proposed models, which have been validated through a wide set of studies within the TAXINOMISIS project, are delivered to the end users through an easy-to-use cloud platform. The architecture and the deployment of this platform includes interfaces for handling the electronic patient record, the 3D arterial reconstruction, blood flow simulations and risk assessment reporting. TAXINOMISIS, compared with both similar software approaches and with the current clinical workflow, assists clinicians to treat patients more effectively and more accurately by providing innovative and validated tools.

“…[116] There has been research into alternative models, including the integration of agent-based models (AGM) with CFD models to simulate arterial wall remodeling and replicate physiological and pathological features in atherosclerotic arteries for more accurate models of plaque growth. [117][118][119] However, with agent-based models, a compromise between the resolution of each biological element and computational cost needs to be conducted initially. [120] Initially, boundary conditions are first established, followed by identifying the number of layers and interfaces used in the model, the type of fluid used (Newtonian or non-Newtonian), the type of flow (laminar or turbulent), and inlet and outlet boundary conditions.…”

Section: Modeling Hemodynamics During Atherosclerotic Initiation and ...mentioning

confidence: 99%

Integrating Computational and Biological Hemodynamic Approaches to Improve Modeling of Atherosclerotic Arteries

Vuong,

Bartolf‐Kopp,

Andelovic

et al. 2024

Advanced Science

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Atherosclerosis is the primary cause of cardiovascular disease, resulting in mortality, elevated healthcare costs, diminished productivity, and reduced quality of life for individuals and their communities. This is exacerbated by the limited understanding of its underlying causes and limitations in current therapeutic interventions, highlighting the need for sophisticated models of atherosclerosis. This review critically evaluates the computational and biological models of atherosclerosis, focusing on the study of hemodynamics in atherosclerotic coronary arteries. Computational models account for the geometrical complexities and hemodynamics of the blood vessels and stenoses, but they fail to capture the complex biological processes involved in atherosclerosis. Different in vitro and in vivo biological models can capture aspects of the biological complexity of healthy and stenosed vessels, but rarely mimic the human anatomy and physiological hemodynamics, and require significantly more time, cost, and resources. Therefore, emerging strategies are examined that integrate computational and biological models, and the potential of advances in imaging, biofabrication, and machine learning is explored in developing more effective models of atherosclerosis.

“…Na slici su prikazani modeli dobijeni automatskim obeležavanjem ultrasonografskih snimakalevo i NMR snimaka -desno kod istog bolesnika. Nakon što automatski prepozna granice lumena, plaka i spoljašnjeg zida, program dalje proračunava osnovne ali i napredne parametre koji su ovde prikazani na slici 1 i 2 20,21 . Nivo 3.…”

Section: Pogled U Budućnost: Stratifikacija Pacijenata Sa Karotidnom ...unclassified

Modern treatment of patients with carotid stenosis

2022

Galenika Med J

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Narrowing of the carotid arteries, carotid stenosis, (CS) is a frequent manifestation of atherosclerosis. It can be associated with other diseases of peripheral blood vessels, stenotic occlusive or aneurysmal, but also coronary arteries. Almost 15% of ischemic strokes are caused by this disease, which shares common risk factors with other atherosclerotic manifestations (age, male gender, hypertension, diabetes, smoking). The disease is progressive and with progression comes the progression of the degree of stenosis, the volume and morphological characteristics of the plaque. As these features progress, they increase the risk of clinical manifestations. Ischemic stroke, transient ischemic attack or transient blindness in the ipsilateral eye (amaurosis fugax) are the only clinical manifestations that can be directly related to carotid stenosis. Ischemic changes in the brain parenchyma, which can be seen on magnetic resonance imaging or computed tomography, are also associated with carotid stenosis. All the mentioned parameters are taken into account when making decisions about further treatment. Available drug therapy includes antiplatelet and statin therapy with control of risk factors (body weight correction, smoking cessation) and associated diseases (hypertension, diabetes, etc.). Invasive treatment includes carotid endarterectomy (CEA) as vascular or carotid stenting (CAS) as endovascular treatment. KEA is performed under local or general anesthesia, increasingly under local anesthesia, and after accessing the carotid arteries through a cervicotomy, they are clamped, the flow is interrupted, and after the artery is opened, plaque removal and endarterectomy are performed. In addition to the anesthesiological management of the patient and the performance of the surgical technique, the monitoring of cerebral perfusion during clamping is an important technical detail in these operations. KAS is performed through a percutaneous transfemoral approach under local anesthesia when a stent is implanted in the carotid artery at the site of the carotid stenosis. To perform this procedure, adequate access is required in terms of the quality of the femoral and iliac blood vessels, i.e. the aortic arch. KAS was introduced into practice much later, and in the last 20 years, there has been a significant improvement both in terms of performance and technology with the development of modern stents and the materials used in their installation. A special contribution to this technique was the introduction of embolization protection. KAS is a complementary method to CEA and an individual approach to the patient enables the choice of method, taking into account the advantages and disadvantages of one and the other method. When it comes to symptomatic patients, CEA certainly has a significantly greater advantage and when the use of CAS should be avoided. Complications of both methods are general, local and neurological, with the latter being the most important. Current recommendations state that performing these procedures is beneficial for the patient if the risk of neurological complications is less than 3% in asymptomatic patients, or less than 6% in symptomatic patients. At the Clinic for Vascular and Univascular Surgery of the Clinical Center of Serbia, in the last fifteen years, almost 9.000 procedures have been performed due to carotid stenosis, of which about 10% (960) were CAS. We opt for this method in patients who are at cardiorespiratory risk for CEA or in whom access to the carotid bifurcation is difficult. All, the CEA procedures are performed under conditions of the cervical block. The improvement of patient stratification and the use of artificial intelligence should in the future help doctors decide on the method of examination and treatment of these patients.

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