Abstract:Background: Late-gadolinium enhanced (LGE)-MRI has revealed atrial fibrotic remodeling in embolic stroke of undetermined source (ESUS) patients comparable to that observed in atrial fibrillation (AFib) patients. The absence of AFib in ESUS patients may be due to differences in the fibrotic substrate characteristics or the lack of triggers needed to initiate AFib. We used simulations in computational models reconstructed from LGE-MRI scans to study the role of atrial fibrosis as a pathophysiological link betwee… Show more
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