Computational modeling and stress analysis of columellar biomechanics

Gizzi, Alessio; Cherubini, Christian; Pomella, Nicola; Persichetti, Paolo; Vasta, Marcello; Filippi, Sandra

doi:10.1016/j.jmbbm.2012.06.006

Cited by 14 publications

(10 citation statements)

References 60 publications

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“…Mechanical anisotropy is achieved by means of complex and specialized architectures of cable-like fibrils and fibers, made of the most diffused protein in nature, i.e., the collagen. It follows that material models commonly employed for biological tissues account for different kinds of anisotropy induced by the collagen cables [10,18,5,13,8]. Moreover, biological tissues are characterized ineluctably by a spatial distribution of the collagen reinforcement whereas unique strong alignments of fibers are in contrast with the function of the organ.…”

Section: Introductionmentioning

confidence: 99%

On three- and two-dimensional fiber distributed models of biological tissues

Vasta

Gizzi

Pandolfi

2014

Probabilistic Engineering Mechanics

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Section: Introductionmentioning

confidence: 99%

On three- and two-dimensional fiber distributed models of biological tissues

Vasta

Gizzi

Pandolfi

2014

Probabilistic Engineering Mechanics

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“…However, most of these multiscale descriptions are based on simplistic models of neuronal dynamics, mechano-electrical coupling, and tissue biomechanics and still need to be refined and generalized to achieve a higher degree of realism and descriptive/predictive power. In particular, other statistical mechanics tools, multiphysics couplings, and more detailed biomechanical and electrophysiological models can be introduced, as performed in modeling studies on different biological systems [224][225][226][227][228][229][230][231][232][233][234]. In addition, to achieve a better description of mechanotransduction, further studies focused on the electrophysiological dissection of mechano-gated current should be performed.…”

Section: Discussionmentioning

confidence: 99%

Biophysics and Modeling of Mechanotransduction in Neurons: A Review

2021

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Mechanosensing is a key feature through which organisms can receive inputs from the environment and convert them into specific functional and behavioral outputs. Mechanosensation occurs in many cells and tissues, regulating a plethora of molecular processes based on the distribution of forces and stresses both at the cell membrane and at the intracellular organelles levels, through complex interactions between cells’ microstructures, cytoskeleton, and extracellular matrix. Although several primary and secondary mechanisms have been shown to contribute to mechanosensation, a fundamental pathway in simple organisms and mammals involves the presence of specialized sensory neurons and the presence of different types of mechanosensitive ion channels on the neuronal cell membrane. In this contribution, we present a review of the main ion channels which have been proven to be significantly involved in mechanotransduction in neurons. Further, we discuss recent studies focused on the biological mechanisms and modeling of mechanosensitive ion channels’ gating, and on mechanotransduction modeling at different scales and levels of details.

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“…It has been demonstrated that these devices can affect the local temperature of internal colon layers, thus leading to unexpected and undesirable effects similar to POI drawbacks. On this line, in particular, hyperelastic-based models are being studied for applications in medical robotics (20,30), taking into account the internal irregularities of intestinal villi (3), intestinal edema (74), and viscoelasticity (10,67). The effect of temperature may play an interesting role in most of these open problems.…”

Section: Discussionmentioning

confidence: 99%

Experimental evidence and mathematical modeling of thermal effects on human colonic smooth muscle contractility

Altomare

Gizzi

Guarino

et al. 2014

American Journal of Physiology-Gastrointestinal and Liver Physi

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It has been shown, in animal models, that gastrointestinal tract (GIT) motility is influenced by temperature; nevertheless, the basic mechanism governing thermal GIT smooth muscle responses has not been fully investigated. Studies based on physiologically tuned mathematical models have predicted that thermal inhomogeneity may induce an electrochemical destabilization of peristaltic activity. In the present study, the effect of thermal cooling on human colonic muscle strip (HCMS) contractility was studied. HCMSs were obtained from disease-free margins of resected segments for cancer. After removal of the mucosa and serosa layers, strips were mounted in separate chambers. After 30 min, spontaneous contractions developed, which were measured using force displacement transducers. Temperature was changed every hour (37, 34, and 31°C). The effect of cooling was analyzed on mean contractile activity, oscillation amplitude, frequency, and contraction to ACh (10(-5) M). At 37°C, HCMSs developed a stable phasic contraction (~0.02 Hz) with a significant ACh-elicited mean contractile response (31% and 22% compared with baseline in the circular and longitudinal axis, respectively). At a lower bath temperature, higher mean contractile amplitude was observed, and it increased in the presence of ACh (78% and 43% higher than the basal tone in the circular and longitudinal axis, respectively, at 31°C). A simplified thermochemomechanical model was tuned on experimental data characterizing the stress state coupling the intracellular Ca(2+) concentration to tissue temperature. In conclusion, acute thermal cooling affects colonic muscular function. Further studies are needed to establish the exact mechanisms involved to better understand clinical consequences of hypothermia on intestinal contractile activity.

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Computational modeling and stress analysis of columellar biomechanics

Cited by 14 publications

References 60 publications

On three- and two-dimensional fiber distributed models of biological tissues

On three- and two-dimensional fiber distributed models of biological tissues

Biophysics and Modeling of Mechanotransduction in Neurons: A Review

Experimental evidence and mathematical modeling of thermal effects on human colonic smooth muscle contractility

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