Computational model of trachea-alveoli gas movement during spontaneous breathing

Jiménez-Posada, L.D.; Maya, Juan C.; Sánchez-Ocampo, M.; López-Isaza, Sergio; Cortes-Ospina, S.; Montagut-Ferizzola, Yeison Javier; Torres, Róbinson

doi:10.1016/j.resp.2021.103767

Respiratory Physiology & Neurobiology

2021

DOI: 10.1016/j.resp.2021.103767

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Computational model of trachea-alveoli gas movement during spontaneous breathing

L.D. Jiménez-Posada

Juan C. Maya

M. Sánchez-Ocampo

et al.

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2024

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Validation of Math Model Using Porous Media for Determining Alveolar CO2 in Ventilated Patients

Jiménez-Posada,

Palacio- Sánchez,

Montagut-Ferizzola

et al. 2024

Critical Care Medicine

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Objectives: To validate a mathematical model using porous media theory for alveolar CO 2 determination in ventilated patients. Design: Mathematical modeling study with prospective clinical validation to simulate CO 2 exchange from bloodstream to airway entrance. Setting: ICU. Patients: Thirteen critically ill patients without chronic or acute lung disease. Interventions: None. Measurements and Main Results: Model outcomes compared with patient data showed correlations for end-tidal CO 2 (EtCO2), area under the CO 2 curve, and PaCO 2 of 0.918, 0.954, and 0.995. Determination coefficients (R 2) were 0.843, 0.910, and 0.990, indicating precision and predictive power. Conclusions: The mathematical model shows potential in pulmonary critical care. Although promising, practical application demands further validation, clinician training, and patient-specific adjustments. The path to clinical use will be iterative, involving validation and education.

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Validation of Math Model Using Porous Media for Determining Alveolar CO2 in Ventilated Patients

Jiménez-Posada,

Palacio- Sánchez,

Montagut-Ferizzola

et al. 2024

Critical Care Medicine

View full text Add to dashboard Cite

show abstract

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Computational model of trachea-alveoli gas movement during spontaneous breathing

Cited by 1 publication

References 22 publications

Validation of Math Model Using Porous Media for Determining Alveolar CO2 in Ventilated Patients

Validation of Math Model Using Porous Media for Determining Alveolar CO2 in Ventilated Patients

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