Computational Methods Are Significant Determinants of the Associations and Definitions of Insulin Resistance Using the Homeostasis Model Assessment in Women of Reproductive Age

Safar, Fatma H.; Mojiminiyi, Olusegun A.; Al-Rumaih, Hazem M.; Diejomaoh, Michael

doi:10.1373/clinchem.2010.152025

Cited by 30 publications

(25 citation statements)

References 33 publications

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“…In another study, HOMA2 more significantly affected the identification of IR and the detection of metabolic syndrome and polycystic ovarian disease than HOMA1 [18]. In this study, HOMA1-IR and HOMA2-IR were not significantly different in their ability to predict the progression to T2DM in the NGT group, but HOMA2, especially HOMA2-β, was more predictive in pre-diabetic and non-diabetic Koreans than HOMA1.…”

Section: Discussionmentioning

confidence: 49%

Comparison of the Usefulness of the Updated Homeostasis Model Assessment (HOMA2) with the Original HOMA1 in the Prediction of Type 2 Diabetes Mellitus in Koreans

et al. 2016

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BackgroundThe original homeostasis model assessment (HOMA1) and the updated HOMA model (HOMA2) have been used to evaluate insulin resistance (IR) and β-cell function, but little is known about the usefulness of HOMA2 for the prediction of diabetes in Koreans. The aim of this study was to demonstrate the usefulness of HOMA2 as a predictor of type 2 diabetes mellitus in Koreans without diabetes.MethodsThe study population consisted of 104,694 Koreans enrolled at a health checkup program and followed up from 2001 to 2012. Participants were divided into a normal glucose tolerance (NGT) group and a pre-diabetes group according to fasting glucose and glycosylated hemoglobin levels. Anthropometric and laboratory data were measured at the baseline checkup, and HOMA values were calculated at the baseline and follow-up checkups. The hazard ratios (HRs) of the HOMA1 and HOMA2 values and the prevalence of diabetes at follow-up were evaluated using a multivariable Cox proportional hazards model and Kaplan-Meier analysis.ResultsAfter adjusting for several diabetes risk factors, all of the HOMA values except 1/HOMA1-β and 1/HOMA2-β in the NGT group were significant predictors of the progression to diabetes. In the NGT group, there was no significant difference in HOMA1-IR (HR, 1.09; 95% confidence interval [CI], 1.04 to 1.14) and HOMA2-IR (HR, 1.11; 95% CI, 1.04 to 1.19). However, in the pre-diabetes group, 1/HOMA2-β was a more powerful marker (HR, 1.29; 95% CI, 1.26 to 1.31) than HOMA1-IR (HR, 1.23; 95% CI, 1.19 to 1.28) or 1/HOMA1-β (HR, 1.14; 95% CI, 1.12 to 1.16). In the non-diabetic group (NGT+pre-diabetes), 1/HOMA2-β was also a stronger predictor of diabetes (HR, 1.27; 95% CI, 1.25 to 1.29) than HOMA1-IR (HR, 1.14; 95% CI, 1.12 to 1.15) or 1/HOMA1-β (HR, 1.13; 95% CI, 1.11 to 1.14).ConclusionHOMA2 is more predictive than HOMA1 for the progression to diabetes in pre-diabetes or non-diabetic Koreans.

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Section: Discussionmentioning

confidence: 49%

Comparison of the Usefulness of the Updated Homeostasis Model Assessment (HOMA2) with the Original HOMA1 in the Prediction of Type 2 Diabetes Mellitus in Koreans

et al. 2016

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“…HOMA-IR score was calculated during the adaptation period, weeks 6, 11, and 12, with a HOMA-IR calculator. 37 Numbers represent means ± SE ( n = 5–8). Means with different letters are significantly different at P < 0.05.…”

Section: Resultsmentioning

confidence: 99%

Imidacloprid Promotes High Fat Diet-Induced Adiposity and Insulin Resistance in Male C57BL/6J Mice

Sun

Xiao

Kim

et al. 2016

J. Agric. Food Chem.

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Imidacloprid, a neonicotinoid insecticide widely used in agriculture worldwide, has been reported to promote adipogenesis and cause insulin resistance in vitro. The purpose of the current study was to determine the effects of imidacloprid and its interaction with dietary fat in the development of adiposity and insulin resistance using male C57BL/6J mice. Imidacloprid (0.06, 0.6, or 6 mg/kg bw/day) was mixed in a low-fat (4% w/w) or high-fat (20% w/w) diet and given to mice ad libitum for 12 weeks. Imidacloprid significantly promoted high fat diet-induced body weight gain and adiposity. In addition, imidacloprid treatment with the high fat diet resulted in impaired glucose metabolism. Consistently, there were significant effects of imidacloprid on genes regulating lipid and glucose metabolisms, including the AMP-activated protein kinase-α (AMPKα) pathway in white adipose tissue and liver. These results suggest that imidacloprid may potentiate high fat diet-induced adiposity and insulin resistance in male C57BL/6J mice.

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“…If the same cut-off has been selected as criterion in this study, more than 10% of healthy lean controls with WC<80 cm would be identified as being IR. Therefore, the use of pre-selected HOMA-IR cut-off for identifying those with IR should be discouraged since, even in the ethnically homogeneous population, substantial differences in HOMA-IR cut-off value used could have an influence on identification of insulin resistant women and therefore, their healthcare management [9,31].…”

Section: Resultsmentioning

confidence: 99%

Definition of insulin resistance using the homeostasis model assessment (HOMA-IR) in IVF patients diagnosed with polycystic ovary syndrome (PCOS) according to the Rotterdam criteria

et al. 2014

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Computational Methods Are Significant Determinants of the Associations and Definitions of Insulin Resistance Using the Homeostasis Model Assessment in Women of Reproductive Age

Cited by 30 publications

References 33 publications

Comparison of the Usefulness of the Updated Homeostasis Model Assessment (HOMA2) with the Original HOMA1 in the Prediction of Type 2 Diabetes Mellitus in Koreans

Comparison of the Usefulness of the Updated Homeostasis Model Assessment (HOMA2) with the Original HOMA1 in the Prediction of Type 2 Diabetes Mellitus in Koreans

Imidacloprid Promotes High Fat Diet-Induced Adiposity and Insulin Resistance in Male C57BL/6J Mice

Definition of insulin resistance using the homeostasis model assessment (HOMA-IR) in IVF patients diagnosed with polycystic ovary syndrome (PCOS) according to the Rotterdam criteria

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