Computational Method in Protein Structure and Function Data

Lin, Hao

doi:10.2174/092986652704200311123651

Cited by 1 publication

(1 citation statement)

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“…Nowadays, novel approaches are established to determine the miRNA-mRNA interaction and underlying mechanisms of action. A computational method is a mathematical approach to merging biology, chemistry, and computer science [ 57 ]. This high-throughput analysis can accurately describe the miRNA-related target genes in various diseases.…”

Section: Approaches To Determine the Targets Of Mir-20bmentioning

confidence: 99%

The dual role of microRNA (miR)-20b in cancers: Friend or foe?

et al. 2023

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MicroRNAs, as non-coding transcripts, modulate gene expression through RNA silencing under normal physiological conditions. Their aberrant expression has strongly associated with tumorigenesis and cancer development. MiR-20b is one of the crucial miRNAs that regulate essential biological processes such as cell proliferation, apoptosis, autophagy, and migration. Deregulated levels of miR-20b contribute to the early- and advanced stages of cancer. On the other hand, investigations emphasize the tumor suppressor ability of miR-20b. High-throughput strategies are developed to identify miR-20b potential targets, providing the proper insight into its molecular mechanism of action. Moreover, accumulated results suggest that miR-20b exerts its effects through diverse signaling pathways, including PI3K/AKT/mTOR and ERK axes. Restoration of the altered expression levels of miR-20b induces cell apoptosis and reduces invasion and migration. Further, miR-20b can be used as a biomarker in cancer. The current comprehensive review could lead to a better understanding of the miR-20b in either tumorigenesis or tumor regression that may open new avenues for cancer treatment.

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Section: Approaches To Determine the Targets Of Mir-20bmentioning

confidence: 99%