Computational insights into the stereo-selectivity of catechins for the inhibition of the cancer therapeutic target EGFR kinase
Mohd Rehan,
Firoz Ahmed,
Mohammad Imran Khan
et al.
Abstract:The epidermal growth factor receptor (EGFR) plays a crucial role in regulating cellular growth and survival, and its dysregulation is implicated in various cancers, making it a prime target for cancer therapy. Natural compounds known as catechins have garnered attention as promising anticancer agents. These compounds exert their anticancer effects through diverse mechanisms, primarily by inhibiting receptor tyrosine kinases (RTKs), a protein family that includes the notable member EGFR. Catechins, characterize… Show more
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