Abstract:G-protein coupled receptors (GPCRs) are eukaryotic integral
membrane
proteins that regulate signal transduction cascade pathways implicated
in a variety of human diseases and are consequently of interest as
drug targets. For this reason, it is of interest to investigate the
way in which specific ligands bind and trigger conformational changes
in the receptor during activation and how this in turn modulates intracellular
signaling. In the present study, we investigate the way in which the
ligand Prostaglandin E… Show more
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