Abstract:The gut contains an enormous diversity of simple as well as complex molecules from highly diverse food sources as well as host-secreted molecules. This presents a large metabolic opportunity for the gut microbiota, but little is known on how gut microbes are able to catabolize this large chemical diversity. Recently, Fe-S flavoenzymes were found to be key in the transformation of bile acids, catalysing the key step in the 7 -dehydroxylation pathway that allows gut bacteria to transform cholic acid (CA) into de… Show more
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