Computational fluid dynamics simulation and particle image velocimetry experimentation of hydrodynamic performance of flat-sheet membrane bioreactor equipped with micro-channel turbulence promoters with micro-pores

Xie, Fang; Liu, Jinrong; Wang, Jianmin; Chen, Weiwei

doi:10.1007/s11814-016-0076-8

Cited by 10 publications

(4 citation statements)

References 30 publications

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“…One of the most fundamental factors is the flow pattern. Particle image velocimetry (PIV) [80][81][82], laser doppler anemometry [83,84] and laser induced fluorescence [81,85] are suitable for measuring the velocities in a bioreactor and are especially used for stirred bioreactors. For orbitally shaken [86,87] and wave-mixed [88] systems, often only the liquid height or distribution is measured.…”

Section: Validationmentioning

confidence: 99%

Computational Fluid Dynamics for Advanced Characterisation of Bioreactors Used in the Biopharmaceutical Industry – Part I: Literature Review

Seidel¹,

Schirmer²,

Maschke³

et al. 2023

Computational Fluid Dynamics - Recent Advances, New Perspectives and Applications

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Computational fluid dynamics (CFD) is a widely used tool for investigating fluid flows in bioreactors. It has been used in the biopharmaceutical industry for years and has established itself as an important tool for process engineering characterisation. As a result, CFD simulations are increasingly being used to complement classical process engineering investigations in the laboratory with spatially and temporally resolved results, or even replace them when laboratory investigations are not possible. Parameters that can be determined include the specific power input, Kolmogorov length, hydrodynamic stress, mixing time, oxygen transfer rate, and for cultivations with microcarriers, the NS1 criterion. In the first part of this series, a literature review illustrates how these parameters can be determined using CFD and how they can be validated experimentally. In addition, an overview of the hardware and software typically used for bioreactor characterisation will also be provided, including process engineering parameter investigations from the literature. In the second part of this series, the authors’ research results will be used to show how the process engineering characterisation of mechanically driven bioreactors for the biopharmaceutical industry (stirred, orbitally shaken, and wave-mixed) can be determined and validated using CFD.

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Section: Validationmentioning

confidence: 99%

Computational Fluid Dynamics for Advanced Characterisation of Bioreactors Used in the Biopharmaceutical Industry – Part I: Literature Review

Seidel¹,

Schirmer²,

Maschke³

et al. 2023

Computational Fluid Dynamics - Recent Advances, New Perspectives and Applications

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“…According to Storck and Hutin [22], the concentration depletion intensified when membrane spacers were introduced to reactors. When Xie et al [26] used particle image velocimetry to examine wall shear stress and velocity profiles at a flat membrane, they found that microchannel turbulence promoters with transverse 300-μm micropores could induce velocity variations and eddy developments.…”

Section: Review Articlementioning

confidence: 99%

“…When Xie et al. 26 used particle image velocimetry to examine wall shear stress and velocity profiles at a flat membrane, they found that microchannel turbulence promoters with transverse 300‐μm micropores could induce velocity variations and eddy developments.…”

Section: Introductionmentioning

confidence: 99%

Electrodialysis with Irregular Membrane Spacers: Which is the Right Choice?

et al. 2023

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Membrane operations function well in turbulent conditions, requiring the use of a turbulence model. By increasing the velocity and generating eddies with membrane spacers, mass transport can be enhanced and permeability can be intensified while reducing concentration polarization. Spacers act as solid barriers for the bulk fluid and have been shown to facilitate mass transfer at channel thicknesses of 1 mm due to eddy promotion. Spacers are used in a variety of membrane processes including nanofiltration, reverse osmosis, electrodialysis, and membrane distillation. Membrane spacers can also be used for other applications such as membrane electrolysis, fuel cells, capacitive deionization, and electrodialysis with bipolar membranes. This work systematically reviews and compares irregular geometries of spacers, including Gyroid, tCLP, multilayered, crimped, and tortuous spacers. The review consistently concludes that the spacer geometrical properties are the primary determinants of the streamline effectiveness.

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“…4.2 are suitable for validation with respect to the k L a value. If the flow field is also subject of validation, methods like particle image velocimetry [269][270][271][272][273][274], laser Doppler anemometry [275][276][277] or laser induced fluorescence [278,279] can be used. If an own CFD code is developed, a verification of the code must also be carried out beforehand [268].…”

Section: Efficiency and Economymentioning

confidence: 99%

Oxygen Mass Transfer in Biopharmaceutical Processes: Numerical and Experimental Approaches

Seidel

Maschke

Werner

et al. 2020

Chemie Ingenieur Technik

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This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. Dedicated to Prof. Dr.-Ing. Matthias Kraume on the occasion of his 65th birthday Oxygen supply in aerobic bioprocesses is of crucial importance. For this reason, this paper presents the oxygen demand of different cells and summarizes experimental and numerical possibilities for the determination of oxygen transfer in bioreactors. The focus lies on the volumetric oxygen mass transfer coefficient (k L a) calculation using computational fluid dynamics and state-of-the-art models for surface-aerated and forced-aerated bioreactors. In addition, experimental methods for the determination of the k L a value and the gas bubble size distribution are presented.

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Computational fluid dynamics simulation and particle image velocimetry experimentation of hydrodynamic performance of flat-sheet membrane bioreactor equipped with micro-channel turbulence promoters with micro-pores

Cited by 10 publications

References 30 publications

Computational Fluid Dynamics for Advanced Characterisation of Bioreactors Used in the Biopharmaceutical Industry – Part I: Literature Review

Computational Fluid Dynamics for Advanced Characterisation of Bioreactors Used in the Biopharmaceutical Industry – Part I: Literature Review

Electrodialysis with Irregular Membrane Spacers: Which is the Right Choice?

Oxygen Mass Transfer in Biopharmaceutical Processes: Numerical and Experimental Approaches

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