Computational fluid dynamics modeling of aerosol particle transport through lung airway mucosa

Bartlett, Blake A.; Feng, Yu; Fromen, Catherine A.; Ford Versypt, Ashlee N.

doi:10.1016/j.compchemeng.2023.108458

Cited by 2 publications

(2 citation statements)

References 57 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The respiratory tract consists of two types of cells: ciliated and secretory cells. The PCL allows the cilia to beat without catching in the mucus and acts as a lubricant that allows the mucus to slide along the interface [146]. Secretory cells are further divided into Clara cells, goblet cells, and submucosal cells [147,148].…”

Section: Mucus Structure In Crdsmentioning

confidence: 99%

Mucus Structure, Viscoelastic Properties, and Composition in Chronic Respiratory Diseases

Abrami,

Biasin,

Tescione

et al. 2024

IJMS

View full text Add to dashboard Cite

The respiratory mucus, a viscoelastic gel, effectuates a primary line of the airway defense when operated by the mucociliary clearance. In chronic respiratory diseases (CRDs), such as asthma, chronic obstructive pulmonary disease (COPD), and cystic fibrosis (CF), the mucus is overproduced and its solid content augments, changing its structure and viscoelastic properties and determining a derangement of essential defense mechanisms against opportunistic microbial (virus and bacteria) pathogens. This ensues in damaging of the airways, leading to a vicious cycle of obstruction and infection responsible for the harsh clinical evolution of these CRDs. Here, we review the essential features of normal and pathological mucus (i.e., sputum in CF, COPD, and asthma), i.e., mucin content, structure (mesh size), micro/macro-rheology, pH, and osmotic pressure, ending with the awareness that sputum biomarkers (mucins, inflammatory proteins and peptides, and metabolites) might serve to indicate acute exacerbation and response to therapies. There are some indications that old and novel treatments may change the structure, viscoelastic properties, and biomarker content of sputum; however, a wealth of work is still needed to embrace these measures as correlates of disease severity in association with (or even as substitutes of) pulmonary functional tests.

show abstract

Section: Mucus Structure In Crdsmentioning

confidence: 99%

Mucus Structure, Viscoelastic Properties, and Composition in Chronic Respiratory Diseases

Abrami,

Biasin,

Tescione

et al. 2024

IJMS

View full text Add to dashboard Cite

show abstract

“…Kuscer et al 24 also found that the distribution of the current density at the electrode boundary influenced the deposition thickness apparently. Many researchers have explored the motion characteristics of particles in the suspension, for example, the particle aggregation in the surface texture of microfluidic channels, 25 the dilute particle transport model in lung airway fluids, 26 and the forced convection of water-alumina nanofluids in square cavities with high Reynolds number. 27 However, few employed the finite element method to analyze the deposition process of EPD.…”

mentioning

confidence: 99%

Parameters Optimization for Electrophoretic Deposition of Mn_1.5Co_1.5O₄ on Ferritic Stainless Steel Based on Multi-Physical Simulation

Zhou,

Mao,

Wang

et al. 2024

J. Electrochem. Soc.

View full text Add to dashboard Cite

Solid oxide fuel cells (SOFCs) are an effective and sustainable energy conversion technology. As operating temperatures decrease, metal interconnects and supports are widely employed in SOFCs. It is critical to apply a protective coat on ferritic stainless steel (FSS) to suppress Cr evaporation and element interdiffusion under high temperatures. Electrophoretic deposition (EPD) is a promising approach for depositing metal oxides on FSS substrate. Here, a method based on 3D multi-physical simulation and orthogonal experimental design was proposed to optimize deposition parameters, including applied voltage, deposition time, and electrode distance. The EPD process to deposit Mn1.5Co1.5O4 particles in a suspension of ethanol and isopropanol was simulated and the effects of these three factors on the film thickness and uniformity were analyzed. The results indicate that applied voltage has the greatest impact on deposition thickness, followed by deposition time and electrode distance. Meanwhile, deposition time exhibits a more significant effect on film unevenness than applied voltage. Additionally, the particle-fluid coupling phenomenon was analyzed during the EPD process. In practice, these deposition parameters must be selected appropriately and the deposition time must be controlled to obtain a uniform coating. The proposed method can reduce cost and shorten the design period.

show abstract

Computational fluid dynamics modeling of aerosol particle transport through lung airway mucosa

Cited by 2 publications

References 57 publications

Mucus Structure, Viscoelastic Properties, and Composition in Chronic Respiratory Diseases

Mucus Structure, Viscoelastic Properties, and Composition in Chronic Respiratory Diseases

Parameters Optimization for Electrophoretic Deposition of Mn_1.5Co_1.5O₄ on Ferritic Stainless Steel Based on Multi-Physical Simulation

Contact Info

Product

Resources

About

Computational fluid dynamics modeling of aerosol particle transport through lung airway mucosa

Cited by 2 publications

References 57 publications

Mucus Structure, Viscoelastic Properties, and Composition in Chronic Respiratory Diseases

Mucus Structure, Viscoelastic Properties, and Composition in Chronic Respiratory Diseases

Parameters Optimization for Electrophoretic Deposition of Mn1.5Co1.5O4 on Ferritic Stainless Steel Based on Multi-Physical Simulation

Contact Info

Product

Resources

About

Parameters Optimization for Electrophoretic Deposition of Mn_1.5Co_1.5O₄ on Ferritic Stainless Steel Based on Multi-Physical Simulation