Computational Fluid Dynamics Modeling for Chromatographic Purification of Free Lutein

Choopakdee, Weerapong; Prasitchoke, Phattanon; Shotipruk, Artiwan; Ponpesh, Pimporn

doi:10.1016/b978-0-444-63455-9.50067-2

Cited by 3 publications

(2 citation statements)

References 13 publications

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“…14 Moreover, CFD-based modeling and numerical simulation have been adopted to explore the transport phenomena in the preparative chromatography column. 13,15–17 In this study, CFD is proposed to explore the hydrodynamics of DAC columns based on up-to-date approaches of flow characterization and then to figure out numerical treatments that can be beneficial to simulations. In this research, CFD is used to access information on the inside of the DAC column, and the flow is considered to be laminar due to low flow speed with adsorption equilibrium in the micro-particle-packed column.…”

Section: Introductionmentioning

confidence: 99%

Simulations of unsteady flows with adsorption equilibrium in dynamic axial compression column

Chen

Tsai

Hsu

2020

Advances in Mechanical Engineering

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Simulated moving bed chromatography process, which is a multicolumn chromatography process, has been used in various industrial applications. Dynamic axial compression columns are key elements in simulated moving beds, and their flow characteristics are worth exploring using state-of-the-art numerical methodologies. In this study, new fluid distributors for the dynamic axial compression column were designed and fabricated based on mass conservation in fluid mechanics and the computer-aided design in the preliminary stage. Computational fluid dynamics was employed to resolve the flow field, and the numerical chromatograms were validated by laboratory experiments. For the computational fluid dynamics–based simulation of flow in the dynamic axial compression, the transient laminar flow fields were described by the momentum and species transport equations with Darcy’s law to model the porous zone in the packed bed. In addition, reverse engineering processes were applied to obtain the unknown physical parameters, such as viscous resistance and adsorption equilibrium coefficients. Moreover, including the adsorption equilibrium equation in the fundamental governing equations made the simulated results agree with the experimental data in chromatograms, providing a more feasible result for practical applications.

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Section: Introductionmentioning

confidence: 99%

Simulations of unsteady flows with adsorption equilibrium in dynamic axial compression column

Chen

Tsai

Hsu

2020

Advances in Mechanical Engineering

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“…Its modelling has been applied to investigate the transport phenomena in the preparative chromatography column [14][15][16]. Therefore, it is proposed to characterize in detailed hydrodynamics of DAC columns based on the recent advances of flow characterisation by CFD, and then to deduce numerical treatments that can be beneficial to simulations.…”

Section: Introductionmentioning

confidence: 99%

Computer aided design and analysis on distributors in DAC columns

Chen¹,

Tse

Cheng

et al. 2018

MATEC Web Conf.

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Abstract. Dynamic axial compression (DAC) columns are key elements in simulated moving bed, which is a chromatography process in drug industry and chemical engineering. In this study, rules for designing distributors are proposed based on mass conservation and validated by experiments, the computer aided design (CAD) and the computational fluid dynamics (CFD). Experimental works are conducted to choose feasible numerical parameters for simulations. In CFD, the transient laminar flow fields are governed by the momentum and species transport equations with Darcy's law to model the porous zone in the packed bed. Results show that CFD combined with CAD solid modelling is a good approach to explore detailed flow fields in DAC columns and carry out parameter analysis for innovative designs. For further testing and evaluation, a new model of compound distributor is designed, 3D printed and processed in factory for practical applications in preparative chromatography.

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Numerical simulations on the flow fields of dynamic axial compression columns in chromatography processes

Liang

Liu

Liang

et al. 2017

J. Phys.: Conf. Ser.

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Computational Fluid Dynamics Modeling for Chromatographic Purification of Free Lutein

Cited by 3 publications

References 13 publications

Simulations of unsteady flows with adsorption equilibrium in dynamic axial compression column

Simulations of unsteady flows with adsorption equilibrium in dynamic axial compression column

Computer aided design and analysis on distributors in DAC columns

Numerical simulations on the flow fields of dynamic axial compression columns in chromatography processes

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