Computational fluid dynamic simulation of two-fluid non-Newtonian nanohemodynamics through a diseased artery with a stenosis and aneurysm

Dubey, Ankita; Vasu, B.; Bég, O. Anwar; Gorla, R. S. R.; Kadir, A

doi:10.1080/10255842.2020.1729755

Cited by 36 publications

(17 citation statements)

References 70 publications

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“…This could include the use of numerical techniques, such as the FEM or finite-volume method (FVM) solvers. Commercial software such as Fluent (Ansys Inc.) or FreeFem + + , an open-source FEM solver used by Dubey et al ( 2020 ), could also be employed in performing the aforementioned CFD simulations. This will enable us to understand what specific factors result in the optimal margination of DCPs to the vessel wall.…”

Section: Discussionmentioning

confidence: 99%

“…In all cases, the employed phenomenological expression refers to the viscosity of neat blood and not of the nanofluid as a whole. Dubey et al ( 2020 ) performed computational fluid dynamics (CFD) simulations, using the FEM, of blood flow through a diseased artery with a stenosis followed by an aneurysm. They adopted two different models to address the rheological behavior of blood: they employed the Casson viscoplastic model (Casson 1959 ; Mitsoulis 2007 ) in the arterial core region, and the viscoelastic Sisko model in the peripheral (close to the arterial wall) region.…”

Section: Introductionmentioning

confidence: 99%

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Elucidating the rheological implications of adding particles in blood

Stephanou

2021

Rheol Acta

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Graphical abstract In the past few decades, nanotechnology has been employed to provide breakthroughs in the diagnosis and treatment of several diseases using drug-carrying particles (DCPs). In such an endeavor, the optimal design of DCPs is paramount, which necessitates the use of an accurate and trustworthy constitutive model in computational fluid dynamics (CFD) simulators. We herein introduce a continuum model for elaborating on the rheological implications of adding particles in blood. The model is developed using non-equilibrium thermodynamics to guarantee thermodynamic admissibility. Red blood cells are modeled as deformed droplets with a constant volume that are able to aggregate, whereas particles are considered rigid spheroids. The model predictions are compared favorably against rheological data for both spherical and non-spherical particles immersed in non-aggregating blood. It is expected that the use of this model will allow for the testing of DCPs in virtual patients and for their tailor-design in treating various diseases. Supplementary Information The online version contains supplementary material available at 10.1007/s00397-021-01289-x.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Elucidating the rheological implications of adding particles in blood

Stephanou

2021

Rheol Acta

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“…The hemodynamics in the diseased abdominal aorta are considered to be a key contributor to the formation and growth of intraluminal thrombus (ILT) in AAA. In order to better understand the basic hemodynamic features in AAA imaging and seek potential treatment, many investigations have been made (98)(99)(100)(101)(102). Juchems et al used computational fluid dynamics (CFD)-based blood flow simulation to analyze dynamic pressure in AAA before and after endovascular repair and provided a prognostic statement as to the possible homogenization of the pressure in abdominal stent grafts (98).…”

Section: Discussionmentioning

confidence: 99%

Nanoparticle-Assisted Diagnosis and Treatment for Abdominal Aortic Aneurysm

et al. 2021

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An abdominal aortic aneurysm (AAA) is a localized dilatation of the aorta related to the regional weakening of the wall structure, resulting in substantial morbidity and mortality with the aortic ruptures as complications. Ruptured AAA is a dramatic catastrophe, and aortic emergencies constitute one of the leading causes of acute death in older adults. AAA management has been centered on surgical repair of larger aneurysms to mitigate the risks of rupture, and curative early diagnosis and effective pharmacological treatments for this condition are still lacking. Nanoscience provided a possibility of more targeted imaging and drug delivery system. Multifunctional nanoparticles (NPs) may be modified with ligands or biomembranes to target agents' delivery to the lesion site, thus reducing systemic toxicity. Furthermore, NPs can improve drug solubility, circulation time, bioavailability, and efficacy after systemic administration. The varied judiciously engineered nano-biomaterials can exist stably in the blood vessels for a long time without being taken up by cells. Here, in this review, we focused on the NP application in the imaging and treatment of AAA. We hope to make an overview of NP-assisted diagnoses and therapy in AAA and discussed the potential of NP-assisted treatment.

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“…Ahmed and Nadeem [20] explored the relative performance of various nanoparticles (Cu, Al2O3 and TiO2) in blood flow through a stenosed artery. Dubey et al [21] very recently performed numerical computations for transient non-Newtonian blood flow conveying nanoparticles through an artery with a combination of stenosis and aneurysm, providing extensive flow visualization in the vicinity of the constriction and expansion in the blood vessel.…”

Section: Introductionmentioning

confidence: 99%

Unsteady hybrid nanoparticle-mediated magneto-hemodynamics and heat transfer through an overlapped stenotic artery: Biomedical drug delivery simulation

Tripathi

Vasu

Bég

et al. 2021

Proc Inst Mech Eng H

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Two-dimensional laminar hemodynamics through a diseased artery featuring an overlapped stenosis was simulated theoretically and computationally. This study presented a mathematical model for the unsteady blood flow with hybrid biocompatible nanoparticles (Silver and Gold) inspired by drug delivery applications. A modified Tiwari-Das volume fraction model was adopted for nanoscale effects. Motivated by the magneto-hemodynamics effects, a uniform magnetic field was applied in the radial direction to the blood flow. For realistic blood behavior, Reynolds’ viscosity model was applied in the formulation to represent the temperature dependency of blood. Fourier’s heat conduction law was assumed and heat generation effects were included. Therefore, the governing equations were an extension of the Navier–Stokes equations with magneto-hydrodynamic body force included. The two-dimensional governing equations were transformed and normalized with appropriate variables, and the mild stenotic approximation was implemented. The strongly nonlinear nature of the resulting dimensionless boundary value problem required a robust numerical method, and therefore the FTCS algorithm was deployed. Validation of solutions for the particular case of constant viscosity and non-magnetic blood flow was included. Using clinically realistic hemodynamic data, comprehensive solutions were presented for silver, and silver-gold hybrid mediated blood flow. A comparison between silver and hybrid nanofluid was also included, emphasizing the use of hybrid nanoparticles for minimizing the hemodynamics. Enhancement in magnetic parameter decelerated the axial blood flow in stenotic region. Colored streamline plots for blood, silver nano-doped blood, and hybrid nano-doped blood were also presented. The simulations were relevant to the diffusion of nano-drugs in magnetic targeted treatment of stenosed arterial diseases.

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Computational fluid dynamic simulation of two-fluid non-Newtonian nanohemodynamics through a diseased artery with a stenosis and aneurysm

Abstract: Co m p u t a tio n al flui d d y n a mi c si m ul a tio n of t w o-flui d n o nn e w t o ni a n n a n o h e m o dy n a mi c s t h r o u g h a di s e a s e d a r t e r y wi t h a s t e n o si s a n d a n e u r y s m D u b ey, A, Vas u, B, B e g, OA, Go rl a, R SR a n d Ka dir, A h t t p

Cited by 36 publications

References 70 publications

Elucidating the rheological implications of adding particles in blood

Elucidating the rheological implications of adding particles in blood

Nanoparticle-Assisted Diagnosis and Treatment for Abdominal Aortic Aneurysm

Unsteady hybrid nanoparticle-mediated magneto-hemodynamics and heat transfer through an overlapped stenotic artery: Biomedical drug delivery simulation

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