A number of models exist to simulate the residence time distribution (RTD) of a system or process. Four of these models known as the tanks in series model, axial dispersion model (ADM), aggregated dead zone model, and the advection dispersion equation, have been used to assess which is most suitable for representing the RTD of a hydrodynamic vortex separator (HDVS) when compared to RTD measurements taken under laboratory conditions on a full-scale 3.4 m diameter unit. Computational fluid dynamics (CFD) is also used to model the HDVS and compare with the RTD models and experimental measurements. It has been shown that the fit by each of the RTD models to observed RTDs vary quite considerably, with the ADM being the most appropriate for the HDVS studied, based on having the highest R 2 t value. Given the number of model variables that influence CFD predictions, the outputs from the CFD models appear to be reasonable.