Computational evaluation of malignant tissue apoptosis in magnetic hyperthermia considering intratumoral injection strategy

Tang, Yundong; Flesch, Rodolfo C.C.; Jin, Tao; He, Minhua

doi:10.1016/j.ijheatmasstransfer.2021.121609

Cited by 11 publications

(3 citation statements)

References 39 publications

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“…5e) is employed to evaluate the magnetic field, anticipate the temperature distribution, and estimate the damaged fraction of biological tissue during magnetic hyperthermia treatment. The treatment temperature distribution in the biological tissue of the proposed physical model can be accurately predicted by solving Pennes’ bio-heat transfer equation 71 (eqn (S11) and (S12)†). Details of the simulation parameters and model are presented in the Experimental section of the ESI †.…”

Section: Resultsmentioning

confidence: 99%

NIR and magnetism dual-response multi-core magnetic vortex nanoflowers for boosting magneto-photothermal cancer therapy

Shen,

Li,

Tan

et al. 2024

Nanoscale

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Section: Resultsmentioning

confidence: 99%

NIR and magnetism dual-response multi-core magnetic vortex nanoflowers for boosting magneto-photothermal cancer therapy

Shen,

Li,

Tan

et al. 2024

Nanoscale

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“…Section 4.1 shows that the PBHT model does not consider important cooling mechanisms, so the results with PBHT considering TBPR may show the best results with a fixed power dissipation, but the results are not a good representation of what happens in practice. In this section, we analyze what happens when the other three cases consider their respective power dissipation to reach a critical maximum temperature inside tumor region by using the method proposed in [38]. The power dissipations of MNPs are 1.45 × 10 6 W m −3 for figure 5(a), 3.14 × 10 6 W m −3 for figure 5(b), 1.33 × 10 6 W m −3 for figure 5(c), and 3.07 × 10 6 W m −3 for figure 5(d).…”

Section: Treatment Temperature Distributions For Different Bio-heat T...mentioning

confidence: 99%

Effect of porous heat transfer model on different equivalent thermal dose methods considering an experiment-based nanoparticle distribution during magnetic hyperthermia

Tang

Wang

Flesch

et al. 2023

J. Phys. D: Appl. Phys.

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Magnetic fluid hyperthermia damages malignant cells by keeping the therapeutic temperature within a specific range after magnetic nanoparticles (MNPs) are exposed to an alternating magnetic field. The temperature distribution inside bio-tissue is usually predicted by a classic Pennes bio-heat transfer equation, which considers a heat source due to a homogeneous distribution for MNPs. Aiming at this problem, this study compares the Pennes model to a porous heat transfer model, named local thermal non-equilibrium equation, by considering an experiment-based MNPs distribution, and evaluates the thermal damage degree for malignant tissue by two different thermal dose methods. In addition, this study evaluates the effect of porosity and different blood perfusion rates on both effective treatment temperature and equivalent thermal dose. Simulation results demonstrate that different bio-heat transfer models can result in significant differences in both the treatment temperature profile and the thermal damage degree for tumor region under the same power dissipation of MNPs. Furthermore, scenarios considering a temperature-dependent blood perfusion rate or a lower porosity can have a positive effect on the temperature distribution inside tumor, while having a lower value in the maximum equivalent thermal dose in both thermal dose evaluation methods.

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“…[4,5] However, the treatment temperature distribution inside the tumor region should be determined by many factors, and the most two important elements are the power dissipation for magnetic nanoparticles (MNPs) and the nanofluid concentration distribution inside the tumor region. [6,7] The heat dissipated by the MNPs is primarily determined by the characteristics of the applied magnetic field and MNPs. [8,9] The concentration distribution depends on the delivery approaches for nanofluid, which can generally be intratumoural injection and systematic delivery.…”

Section: Introductionmentioning

confidence: 99%

Effect of bio-tissue deformation behavior due to intratumoral injection on magnetic hyperthermia

Tang¹,

Zou²,

Flesch³

et al. 2023

Chinese Phys. B

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Thermal damage of malignant tissue is generally determined not only by the characteristics of bio-tissues and nanoparticles but also the nanofluid concentration distributions due to different injection methods during magnetic hyperthermia. The latter has more advantages in improving the therapeutic effect with respect to the former since it is a determining factor for the uniformity of nanofluid concentration distribution inside the tumor region. This study investigates the effect of bio-tissue deformation due to intratumoral injection on the thermal damage behavior and treatment temperature distribution during magnetic hyperthermia, in which both the bio-tissue deformation due to nanofluid injection and the mass diffusion after injection behavior are taken into consideration. The nanofluid flow behavior is illustrated by two different theoretical models in this study, which are Navier–Stokes equation inside syringe needle and modified Darcy’s law inside bio-tissue. The diffusion behavior after nanofluid injection is expressed by a modified convection–diffusion equation. A proposed three-dimensional liver model based on the angiographic data is set to be the research object in this study, in which all bio-tissues are assumed to be deformable porous media. Simulation results demonstrate that the injection point for syringe needle can generally achieve the maximum value in the tissue pressure, deformation degree, and interstitial flow velocity during the injection process, all of which then drop sharply with the distance away from the injection center. In addition to the bio-tissue deformation due to injection behavior, the treatment temperature is also highly relevant to determine both the diffusion duration and blood perfusion rate due to the thermal damage during the therapy.

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Computational evaluation of malignant tissue apoptosis in magnetic hyperthermia considering intratumoral injection strategy

Cited by 11 publications

References 39 publications

NIR and magnetism dual-response multi-core magnetic vortex nanoflowers for boosting magneto-photothermal cancer therapy

NIR and magnetism dual-response multi-core magnetic vortex nanoflowers for boosting magneto-photothermal cancer therapy

Effect of porous heat transfer model on different equivalent thermal dose methods considering an experiment-based nanoparticle distribution during magnetic hyperthermia

Effect of bio-tissue deformation behavior due to intratumoral injection on magnetic hyperthermia

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