Abstract:However, within the same topological structural framework, the C-clade gp120 exhibits coupled motions that are slightly different from those observed for B-clade. Network analysis indicates that the communities in Cclade gp120 differ the most from B-clade gp120. Even though, gp120 from these clades are structurally similar, spatially distant sites may differentially influence conformational motions to modulate the antibody escape in a clade specific manner.
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