Computational design of tissue engineering scaffolds

Hollister, Scott J.; Lin, Cheng-Yu

doi:10.1016/j.cma.2006.09.023

Cited by 103 publications

(56 citation statements)

References 18 publications

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“…[34][35][36][37][38] Our own group has used homogenization theory to extensively predict and optimize effective scaffold properties based on scaffold architecture. [25,[39][40][41] In this approach, local-field equations are solved to determine characteristic field variables. These field variables are then integrated over the architecture volume to determine the effective properties.…”

Section: Scaffold Designmentioning

confidence: 99%

Scaffold Design and Manufacturing: From Concept to Clinic

Hollister¹

2009

Advanced Materials

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360

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Since Robert Langer and colleagues pioneered the concept of reconstructing tissue using cells transplanted on synthetic polymer matrices in the early 1990s, research in the field of tissue engineering and regenerative medicine has exploded. This is especially true in the development of new materials and structures that serve as scaffolds for tissue reconstruction. The basic tenet of the last two decades holds scaffolds as degradable materials providing temporary function while enhancing tissue regeneration through the delivery of biologics. Although a number of new scaffolding materials and structures have been developed in research laboratories, the application of such materials practice even has been extremely limited. This paper argues that better integration of all these factors is needed to bring scaffolds from "concept to clinic". It reviews current work in all these areas and suggests where future work and funding is needed.

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Section: Scaffold Designmentioning

confidence: 99%

Scaffold Design and Manufacturing: From Concept to Clinic

Hollister¹

2009

Advanced Materials

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360

243

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“…Many studies have thus focused on the ability to recapitulate the anatomical shape of cell-based constructs in vitro (3)(4)(5)(6)(7). Bone grafts of the highest utility for reconstructive surgery would be based on "designer scaffolds" shaped into gross geometries specific to the patient and defect being treated (1,(8)(9)(10)(11). The temporomandibular joint (TMJ) condyle has been widely studied as a tissue-engineering model because it cannot be generated easily, if at all, by current methods.…”

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confidence: 99%

Engineering anatomically shaped human bone grafts

Grayson

Fröhlich

Yeager

et al. 2009

Proc. Natl. Acad. Sci. U.S.A.

377

322

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The ability to engineer anatomically correct pieces of viable and functional human bone would have tremendous potential for bone reconstructions after congenital defects, cancer resections, and trauma. We report that clinically sized, anatomically shaped, viable human bone grafts can be engineered by using human mesenchymal stem cells (hMSCs) and a "biomimetic" scaffold-bioreactor system. We selected the temporomandibular joint (TMJ) condylar bone as our tissue model, because of its clinical importance and the challenges associated with its complex shape. Anatomically shaped scaffolds were generated from fully decellularized trabecular bone by using digitized clinical images, seeded with hMSCs, and cultured with interstitial flow of culture medium. A bioreactor with a chamber in the exact shape of a human TMJ was designed for controllable perfusion throughout the engineered construct. By 5 weeks of cultivation, tissue growth was evidenced by the formation of confluent layers of lamellar bone (by scanning electron microscopy), markedly increased volume of mineralized matrix (by quantitative microcomputer tomography), and the formation of osteoids (histologically). Within bone grafts of this size and complexity cells were fully viable at a physiologic density, likely an important factor of graft function. Moreover, the density and architecture of bone matrix correlated with the intensity and pattern of the interstitial flow, as determined in experimental and modeling studies. This approach has potential to overcome a critical hurdle-in vitro cultivation of viable bone grafts of complex geometries-to provide patient-specific bone grafts for craniofacial and orthopedic reconstructions.biomimetic | bioreactor | craniofacial regeneration | mesenchymal stem cells | temporomandibular joint | tissue engineering

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“…Homogenous scaffolds or scaffolds of constant porosity are a common assumption employed in tissue engineering simulations. Many reports confirm that this to be a good assumption and useful in calculating scaffold permeability [25,26]. However, many issues arise when considering uniform scaffold permeability.…”

Section: )mentioning

confidence: 91%

Applications of Computational Modelling and Simulation of Porous Medium in Tissue Engineering

German

Madihally

2016

Computation

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Abstract:In tissue engineering, porous biodegradable scaffolds are used as templates for regenerating required tissues. With the advances in computational tools, many modeling approaches have been considered. For example, fluid flow through porous medium can be modeled using the Brinkman equation where permeability of the porous medium has to be defined. In this review, we summarize various models recently reported for defining permeability and non-invasive pressure drop monitoring as a tool to validate dynamic changes in permeability. We also summarize some models used for scaffold degradation and integrating mass transport in the simulation.

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Computational design of tissue engineering scaffolds

Cited by 103 publications

References 18 publications

Scaffold Design and Manufacturing: From Concept to Clinic

Scaffold Design and Manufacturing: From Concept to Clinic

Engineering anatomically shaped human bone grafts

Applications of Computational Modelling and Simulation of Porous Medium in Tissue Engineering

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