Background: A large number of neurology case reports have been published, but it is a challenging task for human medical experts to explore all of these publications. Text mining offers a computational approach to investigate neurology literature and capture meaningful patterns. The overarching goal of this study is to provide a new perspective on case reports of neurological disease and syndrome analysis over the last six decades using text mining.Methods: We extracted diseases and syndromes (DsSs) from more than 65,000 neurology case reports from 66 journals in PubMed over the last six decades from 1955 to 2017. Text mining was applied to reports on the detected DsSs to investigate high-frequency DsSs, categorize them, and explore the linear trends over the 63-year time frame.Results: The text mining methods explored high-frequency neurologic DsSs and their trends and the relationships between them from 1955 to 2017. We detected more than 18,000 unique DsSs and found 10 categories of neurologic DsSs. While the trend analysis showed the increasing trends in the case reports for top-10 high-frequency DsSs, the categories had mixed trends.Conclusion: Our study provided new insights into the application of text mining methods to investigate DsSs in a large number of medical case reports that occur over several decades. The proposed approach can be used to provide a macro level analysis of medical literature by discovering interesting patterns and tracking them over several years to help physicians explore these case reports more efficiently.reports that contain single or multiple cases. Medical case reports (MCRs) usually represent rare cases that are the only evidence before published trials [1]. MCRs are "a formal summary of a unique patient and his or her illness, including the presenting signs and symptoms, diagnostic studies, treatment course and outcome" [2], and are sometimes the first reportage of new discoveries [3]. However, there is no standard format for MCRs and it is difficult to get a macro level perspective [3]. Moreover, MCRs have been historically considered as a cost-and time-effective method in advancing knowledge and education from both patient and physician perspectives with direct impact on clinical practice and patient care [4]. They have several benefits including the presentation of new applications, discussion of new diseases and syndromes (DsSs), generation of hypotheses and novel solutions, and providing educational value to the medical professions [3]. In the late 1990s, interest in MCRs grew. For example, the Lancet introduced a peer-reviewed "Case Reports" section and some new journals were launched for the sole purpose of publishing MCRs [3].The increasing number of published neurology case reports makes the macro level analysis almost impossible because it is a challenge for researchers to keep up-to-date with published medical case reports. Moreover, the number of case series is far fewer than the number of single case reports [5]. This issue requires a new approach to review neur...