In recent work, we numerically and experimentally demonstrated a new approach to high-contrast wavefront control based on the combination of nonlinear optimization with algorithmic differentiation, which we termed algorithmic differentiation wavefront control (ADWC). ADWC is more computationally efficient than Jacobianbased control algorithms for deformable mirror (DM) actuator counts and focal plane sizes relevant to the planned Habitable Worlds Observatory, which potentially opens a path toward on-orbit wavefront sensing and control. Here, we review these results with a view toward their potential impact on NASA's planned Habitable Worlds Observatory and describe ongoing simulations and experiments, including extensions to adaptive control.