Computational biomedical simulations of hybrid nanoparticles (<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" altimg="si50.svg"><mml:mrow><mml:mi mathvariant="italic">Au</mml:mi><mml:mo linebreak="badbreak">-</mml:mo><mml:msub><mml:mrow><mml:mi mathvariant="italic">Al</mml:mi></mml:mrow><mml:mrow><mml:mn>2</mml:mn></mml:mrow></mml:msub><mml:msub><mml:mrow><mml:mi>O</mml:mi></mml:mrow><mml:mrow><mml:mn>3</mml:mn></mml:mrow></mml:msub><mml:mo>/</mml:mo></mml:mrow></mml:math> blood-mediated) transpor

Poonam,; Sharma, Bhupendra K.; Kumawat, Chandan; Vafai, Kambiz

doi:10.1016/j.cplett.2022.139666

Cited by 31 publications

(7 citation statements)

References 71 publications

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“…These cells significantly impact the biomechanical properties of blood. The variability of blood viscosity is influenced by the spatial arrangement of its particles, which is a crucial factor examined in the subsequent model proposed in this study 63 . where , signifies the maximum level of hematocrit with as constant.…”

Section: Mathematical Formulationmentioning

confidence: 99%

“…Based on the previously mentioned assumption regarding magnetohydrodynamic (MHD) interaction, the governing equations are provided as follows 63 , 64 :…”

Section: Mathematical Formulationmentioning

confidence: 99%

“…In consideration of the dimensionless parameters delineated in the nomenclature, the pertinent Eqs. ( 13 )–( 21 ) that govern the model under the assumption of mild stenosis and the condition can be expressed as follows 63 : …”

Section: Mathematical Formulationmentioning

confidence: 99%

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Entropy generation optimization for the electroosmotic MHD fluid flow over the curved stenosis artery in the presence of thrombosis

Sharma,

Khanduri,

Mishra

et al. 2023

Sci Rep

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The present study deals with the entropy generation analysis on the flow of an electrically conductive fluid (Blood) with $$\hbox {Al}_2\hbox {O}_3$$ Al 2 O 3 -suspended nanoparticles through the irregular stenosed artery with thrombosis on the catheter. The fluid flow can be actuated by the interactions of different physical phenomena like electroosmosis, radiation, Joule heating and a uniform radial magnetic field. The analysis of different shapes and sizes of the nanoparticle is considered by taking the Crocine model. The velocity, temperature, and concentration distributions are computed using the Crank–Nicholson method within the framework of the Debye–Huckel linearization approximation. In order to see how blood flow changes in response to different parameters, the velocity contour is calculated. The aluminium oxide nanoparticles employed in this research have several potential uses in biomedicine and biosensing. The surface’s stability, biocompatibility, and reactivity may be enhanced by surface engineering, making the material effective for deoxyribonucleic acid sensing. It may be deduced that the velocity profile reduces as the nanoparticle’s size grows while depicts the reverse trend for the shape size. In a region close to the walls, the entropy profile decreases, while in the region in the middle, it rises as the magnetic field parameter rises. The present endeavour can be beneficial in biomedical sciences in designing better biomedical devices and gaining insight into the hemodynamic flow for treatment modalities.

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Section: Mathematical Formulationmentioning

confidence: 99%

“…Based on the previously mentioned assumption regarding magnetohydrodynamic (MHD) interaction, the governing equations are provided as follows 63 , 64 :…”

Section: Mathematical Formulationmentioning

confidence: 99%

See 1 more Smart Citation

Entropy generation optimization for the electroosmotic MHD fluid flow over the curved stenosis artery in the presence of thrombosis

Sharma,

Khanduri,

Mishra

et al. 2023

Sci Rep

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“…Subject to the above mention assumption with the MHD flow interaction, the resultant governing equations becomes 50,51 :…”

Section: Mathematical Formulationmentioning

confidence: 99%

Hall and ion slip effects on hybrid nanoparticles (Au-GO/blood) flow through a catheterized stenosed artery with thrombosis

Khanduri

Sharma

2022

Proceedings of the Institution of Mechanical Engineers, Part C:

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Present paper deals with the effect of Hall and ion slips on MHD blood flow through a catheterized multi-stenosis artery with thrombosis. Blood is considered a base fluid, and the suspension of Au and GO nanoparticles are used to form the hybrid nano-blood suspension. The hemodynamic mathematical model is presented to mimic the blood flow inside the artery subjected to Joule heating, thermal radiation, Hall and ion slip effects. The effect of the shape of nanoparticles and the variable viscosity depending upon hematocrit is taken into account. The mathematical model is presented in a curvilinear coordinate system, and a mild stenosis assumption is used to get the closed-form solutions. The reduced governing equations are solved using the Crank Nicholson scheme with “MATLAB.” The effect of various pertinent parameters on flow patterns are illustrated graphically. It is observed that increasing the Hall and ion slips parameter causes the increment in the fluid velocity due to an enhancement in the cyclotron frequency of the particles. The hybrid nanoparticles Au-GO/blood has a higher temperature profile than pure blood and unitary nanoparticles, as the thermal conductivity increases with an increase in nanoparticle concentration. Scientists and clinical researchers may find the present study useful in understanding the various illness’s conditions, including cancers, infections, and the removal of blood clots. Furthermore, current research may be helpful in the biomedical area, such as magnetic resonance angiography (MRA), which creates an image of an artery to identify any abnormalities in the artery. The current findings are consistent with recent findings in earlier blood flow research studies.

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“…This study discussed the flow phenomena by considering blood as single-phase fluid rather than a two-phase and also neglected the induced magnetic field effect in comparison with an external magnetic field. In a recent study, Poonam et al (2022) used the Crank-Nicolson technique to computationally examine the impact of a hybrid nanofluid consisting of (Au-Al 2 O 3 /blood) within a curved artery. This research work included situations involving both stenosis and aneurysm in arterial circumstances, enhancing the research authenticity.…”

Section: Introductionmentioning

confidence: 99%

Computer simulation of two phase power-law nanofluid of blood flow through a curved overlapping stenosed artery with induced magnetic field: entropy generation optimization

Kumawat,

Sharma,

Muhammad

et al. 2023

HFF

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Purpose The purpose of this study is to determine the impact of two-phase power law nanofluid on a curved arterial blood flow under the presence of ovelapped stenosis. Over the past couple of decades, the percentage of deaths associated with blood vessel diseases has risen sharply to nearly one third of all fatalities. For vascular disease to be stopped in its tracks, it is essential to understand the vascular geometry and blood flow within the artery. In recent scenarios, because of higher thermal properties and the ability to move across stenosis and tumor cells, nanoparticles are becoming a more common and effective approach in treating cardiovascular diseases and cancer cells. Design/methodology/approach The present mathematical study investigates the blood flow behavior in the overlapped stenosed curved artery with cylinder shape catheter. The induced magnetic field and entropy generation for blood flow in the presence of a heat source, magnetic field and nanoparticle (Fe3O4) have been analyzed numerically. Blood is considered in artery as two-phases: core and plasma region. Power-law fluid has been considered for core region fluid, whereas Newtonian fluid is considered in the plasma region. Strongly implicit Stone’s method has been considered to solve the system of nonlinear partial differential equations (PDE’s) with 10–6 tolerance error. Findings The influence of various parameters has been discussed graphically. This study concludes that arterial curvature increases the probability of atherosclerosis deposition, while using an external heating source flow temperature and entropy production. In addition, if the thermal treatment procedure is carried out inside a magnetic field, it will aid in controlling blood flow velocity. Originality/value The findings of this computational analysis hold great significance for clinical researchers and biologists, as they offer the ability to anticipate the occurrence of endothelial cell injury and plaque accumulation in curved arteries with specific wall shear stress patterns. Consequently, these insights may contribute to the potential alleviation of the severity of these illnesses. Furthermore, the application of nanoparticles and external heat sources in the discipline of blood circulation has potential in the medically healing of illness conditions such as stenosis, cancer cells and muscular discomfort through the usage of beneficial effects.

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Computational biomedical simulations of hybrid nanoparticles (Au-Al2O3/ blood-mediated) transpor

Cited by 31 publications

References 71 publications

Entropy generation optimization for the electroosmotic MHD fluid flow over the curved stenosis artery in the presence of thrombosis

Entropy generation optimization for the electroosmotic MHD fluid flow over the curved stenosis artery in the presence of thrombosis

Hall and ion slip effects on hybrid nanoparticles (Au-GO/blood) flow through a catheterized stenosed artery with thrombosis

Computer simulation of two phase power-law nanofluid of blood flow through a curved overlapping stenosed artery with induced magnetic field: entropy generation optimization

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