Computational Approaches in Reproductomics

Vargas, E; Esteban, Francisco J.; Altmäe, Signe

doi:10.1016/b978-0-12-812571-7.00019-8

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2022

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“…Previous data mining and review studies have presented CD55 and CFD as putative biomarker of endometrial receptivity (26)(27)(28)(29)(30). In this study, the relative expression of complement system including CD55 and CFD was significantly lower in PCOS women than in controls.…”

Section: Discussionmentioning

confidence: 50%

Molecular signature of immunological mechanism behind impaired endometrial receptivity in polycystic ovarian syndrome

Amjadi¹,

Zandieh²,

Mehdizadeh³

et al. 2022

Archives of Endocrinology and Metabolism

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Objective: Despite the treatment of anovulation, infertility is still one of the main complications in PCOS women during reproductive age, which appears to be mainly due to impaired uterine receptivity. This study investigated the transcriptome profiles of endometrium in PCOS patients and healthy fertile individuals as the control group. Material and methods: Total mRNA was extracted from endometrial tissues of PCOS patients (n = 12) and healthy fertile individuals (n = 10) during the luteal phase. After cDNA synthesis, PCR array was performed using Human Female Infertility RT² Profiler PCR Array kit (Qiagen, Cat.No: PAHS-164Z) for evaluating expression of 84 genes contributing to the female infertility. Results: PCR Array data analysis identified significantly greater expression of CSF,

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