Computational and experimental study on the interaction of three novel rare earth complexes containing 2,9-dimethyl-1,10-phenanthroline with human serum albumin

New transition metal complexes of 9,10‐phenanthrenequinone p‐toluyl hydrazone Schiff base: Synthesis, spectroscopy, DNA and HSA interactions, antimicrobial, DFT and docking studies

“…The reduction of fluorescence intensity of a fluorophore is referred to as fluorescence quenching. The quenching of HSA fluorescence obviously showed that these compounds were bound to HSA and did not change the environment around the Trp‐214 residue and the tertiary structure of HSA …”

“…The quenching of HSA fluorescence obviously showed that these compounds were bound to HSA and did not change the environment around the Trp-214 residue and the tertiary structure of HSA. [55][56][57] In order to study the quenching process and to estimate the possible quenching mechanism, the Stern-Volmer equation was performed with Equation (1). The values of K SV for the interaction of HSA with these compounds, at four temperatures (292, 295, 298, and 301 K), were estimated as the slope of F 0 /F vs [Q] linear plot, and the results are shown in Figures 13d-13f and indicated in Table 6.…”

In vitro anticancer activity of parent and nano-encapsulated samarium(iii) complex towards antimicrobial activity studies and FS-DNA/BSA binding affinity

“…8 Furthermore, serum albumins are the most abundant protein in blood that show signicant role in the distribution, metabolism, and transport of various exogenous compounds (containing drugs, amino acids, fatty acids, and pharmaceuticals). 10 In continuation of recent research work, [11][12][13][14][15][16][17] the synthesis, characterization, and interaction of the Sm-complex, [Sm(bpy) 2 Cl 3 (OH 2 )] (Scheme 1), with FS-DNA and BSA by different types of experimental techniques and docking calculation are reported in this paper. Moreover, the parent, lipid nano-encapsulated (LNEP) and starch nano-encapsulated Scheme 1 Chemical structure of the Sm-complex.…”

Parent and nano-encapsulated ytterbium(iii) complex toward binding with biological macromolecules, in vitro cytotoxicity, cleavage and antimicrobial activity studies

“…The ytterbium-complex was prepared according to previously reported in our earlier work. 21 Electronic absorption measurements were carried out using the Analytik Jena SPEC ORD S100 spectrometer at room temperature. Fluorescence experiments were performed on a PERKIN ELMER, LS-3 equipped with thermostat cell compartment which kept temperature constant within AE0.1 C. Fluorescence titration carried out at different temperatures (290, 295, 298, 301, and 303 K).…”

“…Nanocapsules offer a broad range of interesting features over their micro-sized counterparts as they hold more surface area, have enhanced solubility, signicantly higher biocompatibility, biodegradability, stability during storage, and controlled release. 18,19 In continuation of our previous paper, [20][21][22][23][24][25] we decided to expose the luminescence of the Yb(III) containing Me 2 Phen ligand, [Yb(Me 2 Phen) 2 Cl 3 (OH 2 )] and to introduce it as a novel probe to BSA (Bovine Serum Albumin) and FS-DNA (Fish-Salmon DNA). Thus, the binding of the ytterbium complex with BSA and FS-DNA was examined by emission spectroscopy, UV-vis titration, viscosity measurement, CD spectroscopy, and docking method.…”