Computational analysis of propeptide‐containing proteins and prediction of their post‐cleavage conformation changes
Jimin Pei,
Lisa N. Kinch,
Qian Cong
Abstract:A propeptide is removed from a precursor protein to generate its active or mature form. Propeptides play essential roles in protein folding, transportation, and activation and are present in about 2.3% of reviewed proteins in the UniProt database. They are often found in secreted or membrane‐bound proteins including proteolytic enzymes, hormones, and toxins. We identified a variety of globular and nonglobular Pfam domains in protein sequences designated as propeptides, some of which form intramolecular interac… Show more
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