Computational analysis of PhospholipaseA2 in the honey bee venom

Pattabhiramaiah, Mahesh; Ramesh, Keerthi; Kv, Vishwanath; Reddy, Shankar Muniswamy

doi:10.1080/00218839.2020.1754589

Cited by 6 publications

(5 citation statements)

References 33 publications

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“…It hydrolyzes the sn-2 fatty acyl ester bond of membrane glycerol-3-phospholipids to liberate fatty acids and lysophospholipids, and this catalytic activity disrupts cell membranes, contributing to its anti-tumor, anti-infectivity, and other effects (Putz et al, 2007;Carpena et al, 2020). Besides, the abundant amino acids in bvPLA 2 , leucine and lysine, promotes the phenomenon of neurotoxicity (Pattabhiramaiah et al, 2020).…”

Section: Bee Venom Phospholipase Amentioning

confidence: 99%

Experimental and computational aspects of bioactive proteins from animal venoms: An insight into pharmacological properties and drug discovery

2024

Frontiers Research Topics

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Frontiers is more than just an open access publisher of scholarly articles: it is a pioneering approach to the world of academia, radically improving the way scholarly research is managed. The grand vision of Frontiers is a world where all people have an equal opportunity to seek, share and generate knowledge. Frontiers provides immediate and permanent online open access to all its publications, but this alone is not enough to realize our grand goals. Frontiers journal seriesThe Frontiers journal series is a multi-tier and interdisciplinary set of openaccess, online journals, promising a paradigm shift from the current review, selection and dissemination processes in academic publishing. All Frontiers journals are driven by researchers for researchers; therefore, they constitute a service to the scholarly community. At the same time, the Frontiers journal series operates on a revolutionary invention, the tiered publishing system, initially addressing specific communities of scholars, and gradually climbing up to broader public understanding, thus serving the interests of the lay society, too. Dedication to qualityEach Frontiers article is a landmark of the highest quality, thanks to genuinely collaborative interactions between authors and review editors, who include some of the world's best academicians. Research must be certified by peers before entering a stream of knowledge that may eventually reach the public -and shape society; therefore, Frontiers only applies the most rigorous and unbiased reviews. Frontiers revolutionizes research publishing by freely delivering the most outstanding research, evaluated with no bias from both the academic and social point of view. By applying the most advanced information technologies, Frontiers is catapulting scholarly publishing into a new generation. What are Frontiers Research Topics?Frontiers Research Topics are very popular trademarks of the Frontiers journals series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area.

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Section: Bee Venom Phospholipase Amentioning

confidence: 99%

Experimental and computational aspects of bioactive proteins from animal venoms: An insight into pharmacological properties and drug discovery

2024

Frontiers Research Topics

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“…Bee venom is an odorless, translucent fluid with pungent scent ( Wehbe et al, 2019 , Kim et al, 2020a , Kim et al, 2020b , Pattabhiramaiah et al, 2020 , Choi et al, 2021 ). It has an unpleasant taste and pH from 4.5 to 5.5 ( Ali, 2012 , Abdela and Jilo, 2016 , Pattabhiramaiah et al, 2020 ). It is dissolvable in water and insoluble in ammonium sulfate as well as alcohol ( Hossen et al, 2017a , Hossen et al, 2017b ).…”

Section: Physical Properties Of Honey Bee Venommentioning

confidence: 99%

“…The name has been given because of its biotic property of histamine released from mast cells ( Pucca et al, 2019 ). The enzymes in BV are hyaluronidase and phospholipase ( Zhang et al, 2018 , Kim et al, 2020a , Kim et al, 2020b , Pattabhiramaiah et al, 2020 , Badawi, 2021 ).…”

Section: Chemical Composition Of Honey Bee Venommentioning

confidence: 99%

“…It has been documented that melittin possesses anti-fungal activity ( Rady et al, 2017 , Pattabhiramaiah et al, 2020 ) against Candida albicans by destroying membrane and causing the cell apoptosis in a caspase/mitochondrial-dependent way ( Liu Cui-Cui et al, 2016 ). Also, BV is a strong agent against Trichophyton rubrum , Trichophyton mentagrophytes ( El-Seedi et al, 2020 ), Malassezia furfur and Candida albicans ( Kim et al, 2019 , Kurek-Górecka et al, 2020 ).…”

Section: Pharmacological Properties Of Honey Bee Venommentioning

confidence: 99%

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Pharmacological properties and therapeutic potential of honey bee venom

Ullah¹,

Aldakheel²,

Anjum³

et al. 2023

Saudi Pharmaceutical Journal

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“…It hydrolyzes the sn-2 fatty acyl ester bond of membrane glycerol-3-phospholipids to liberate fatty acids and lysophospholipids, and this catalytic activity disrupts cell membranes, contributing to its anti-tumor, anti-infectivity, and other effects ( Putz et al, 2007 ; Carpena et al, 2020 ). Besides, the abundant amino acids in bvPLA 2 , leucine and lysine, promotes the phenomenon of neurotoxicity ( Pattabhiramaiah et al, 2020 ).…”

Section: Main Components Of Bee Venommentioning

confidence: 99%

Pharmacological effects and mechanisms of bee venom and its main components: Recent progress and perspective

Shi

Xie²,

Yang³

et al. 2022

Front. Pharmacol.

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Bee venom (BV), a type of defensive venom, has been confirmed to have favorable activities, such as anti-tumor, neuroprotective, anti-inflammatory, analgesic, anti-infectivity effects, etc. This study reviewed the recent progress on the pharmacological effects and mechanisms of BV and its main components against cancer, neurological disorders, inflammatory diseases, pain, microbial diseases, liver, kidney, lung and muscle injury, and other diseases in literature during the years 2018–2021. The related target proteins of BV and its main components against the diseases include Akt, mTOR, JNK, Wnt-5α, HIF-1α, NF-κB, JAK2, Nrf2, BDNF, Smad2/3, AMPK, and so on, which are referring to PI3K/Akt/mTOR, MAPK, Wnt/β-catenin, HIF-1α, NF-κB, JAK/STAT, Nrf2/HO-1, TrkB/CREB/BDNF, TGF-β/Smad2/3, and AMPK signaling pathways, etc. Further, with the reported targets, the potential effects and mechanisms on diseases were bioinformatically predicted via Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway, disease ontology semantic and enrichment (DOSE) and protein-protein interaction (PPI) analyses. This review provides new insights into the therapeutic effects and mechanisms of BV and its main components on diseases.

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Computational analysis of PhospholipaseA2 in the honey bee venom

Cited by 6 publications

References 33 publications

Experimental and computational aspects of bioactive proteins from animal venoms: An insight into pharmacological properties and drug discovery

Experimental and computational aspects of bioactive proteins from animal venoms: An insight into pharmacological properties and drug discovery

Pharmacological properties and therapeutic potential of honey bee venom

Pharmacological effects and mechanisms of bee venom and its main components: Recent progress and perspective

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