Computational analysis of nitric oxide biotransport in a microvessel influenced by red blood cells

Wei, Yajie; Mu, Lizhong; Querleux, Bernard; Shen, Zaiyi; He, Ying

doi:10.1016/j.mvr.2019.04.008

Cited by 13 publications

(6 citation statements)

References 50 publications

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“…In addition to the modeling of NO delivery in medium or large arteries, NO distribution in an ideal tubular arteriole was recently evaluated, which further considered the movements of red blood cells. The study illustrated that the permeability of red blood cells would largely determine the NO delivery process and atherosclerotic progression in microvessels [45,46]. Two computational approaches have recently been proposed to simplify the modeling of NO delivery.…”

Section: Diagnosing the Endothelial Function And Atherosclerosis Development Through Computational Modeling Of No Deliverymentioning

confidence: 99%

Delivery of Nitric Oxide in the Cardiovascular System: Implications for Clinical Diagnosis and Therapy

Zhang

Chen

et al. 2021

IJMS

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Nitric oxide (NO) is a key molecule in cardiovascular homeostasis and its abnormal delivery is highly associated with the occurrence and development of cardiovascular disease (CVD). The assessment and manipulation of NO delivery is crucial to the diagnosis and therapy of CVD, such as endothelial dysfunction, atherosclerotic progression, pulmonary hypertension, and cardiovascular manifestations of coronavirus (COVID-19). However, due to the low concentration and fast reaction characteristics of NO in the cardiovascular system, clinical applications centered on NO delivery are challenging. In this tutorial review, we first summarized the methods to estimate the in vivo NO delivery process, based on computational modeling and flow-mediated dilation, to assess endothelial function and vulnerability of atherosclerotic plaque. Then, emerging bioimaging technologies that have the potential to experimentally measure arterial NO concentration were discussed, including Raman spectroscopy and electrochemical sensors. In addition to diagnostic methods, therapies aimed at controlling NO delivery to regulate CVD were reviewed, including the NO release platform to treat endothelial dysfunction and atherosclerosis and inhaled NO therapy to treat pulmonary hypertension and COVID-19. Two potential methods to improve the effectiveness of existing NO therapy were also discussed, including the combination of NO release platform and computational modeling, and stem cell therapy, which currently remains at the laboratory stage but has clinical potential for the treatment of CVD.

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Section: Diagnosing the Endothelial Function And Atherosclerosis Development Through Computational Modeling Of No Deliverymentioning

confidence: 99%

Delivery of Nitric Oxide in the Cardiovascular System: Implications for Clinical Diagnosis and Therapy

Zhang

Chen

et al. 2021

IJMS

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“…Moreover, beyond ATP release, RBCs are also recognized as potential scavengers of NO, a vasodilator 59 . Therefore, a comprehensive investigation is required to unveil the intricate interplay between factors such as the cell-free layer (CFL), ATP concentration, RBC concentrations, Ca 2+ concentration, and their combined effects on the bioavailability of NO within the vascular wall.…”

Section: Discussionmentioning

confidence: 99%

Endothelial Calcium Dynamics Elicited by ATP Release from Red Blood Cells

Nayak,

Das,

Misbah

2023

Preprint

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Red blood cells (RBCs) exhibit an interesting response to hydrodynamic flow, releasing adenosine triphosphate (ATP). Subsequently, these liberated ATP molecules initiate a crucial interaction with endothelial cells (ECs), thereby setting off a cascade involving the release of calcium ions (Ca2+). Ca2+ exerts control over a plethora of cellular functions, and acts as a mediator for dilation and contraction of blood vessel walls. This study focuses on the relationship between RBC dynamics and Ca2+ dynamics, based on numerical simulations under Poiseuille flow within a linear two-dimensional channel. It is found that the concentration of ATP depends upon a variety of factors, including RBC density, channel width, and the vigor of the flow. The results of our investigation reveals several features. Firstly, the peak amplitude of Ca2+ per EC escalates in direct proportion to the augmentation of RBC concentration. Secondly, increasing the flow strength induces a reduction in the time taken to reach the peak of Ca2+ concentration, under the condition of a constant channel width. Additionally, when flow strength remains constant, an increase in channel width corresponds to an elevation in calcium peak amplitude, coupled with a decrease in peak time. This implies that Ca2+ signals should transition from relatively unconstrained channels to more confined pathways within real vascular networks. This notion gains support from our examination of calcium propagation in a linear channel. In this scenario, localized calcium release initiates a propagating wave that gradually encompasses the entire channel. Notably, our computed propagation speed agrees with observations.

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“…Besides, the NO distribution in the idealized arterioles was evaluated with the further consideration of flowing red blood cells. The study illustrated that the permeability of red blood cells would largely determine the NO delivery process in microvessel [48,49]. However, none of the above studies have assessed the NO delivery process in the pathological artery.…”

Section: The Implication Of Nitric Oxide Delivery Analysis In Diagnosing the Endothelial Function And Atherosclerosis Developmentmentioning

confidence: 99%

The Delivery of Nitric Oxide in the Cardiovascular System: Implication for Clinical Diagnosis and Therapy

Ma¹,

Zhang²,

Chen³

et al. 2021

Preprint

View full text Add to dashboard Cite

Nitric oxide (NO) is a key molecule in cardiovascular homeostasis and its abnormal delivery is highly associated with the occurrence and development of cardiovascular disease (CVD). The assessment and manipulation of NO delivery is crucial to the diagnosis and therapy of CVD, such as endothelial dysfunction, atherosclerotic progression, pulmonary hypertension, and cardiovascular manifestations of Coronavirus (COVID-19). However, due to the low concentration and fast reaction characteristics of NO in cardiovascular system, the clinical applications centered on the NO delivery are challenging. In this tutorial review, we first summarized the methods to estimate the in vivo NO delivery process based on the clinical images and mathematical modeling to assess the endothelial function and vulnerability of atherosclerotic plaque. Then, the emerging bioimaging technologies that have the potential to directly measure the arterial NO concentration were discussed, including the Raman spectroscopy and electrochemical sensor. Aside from the diagnostic methods, therapies aimed at controlling NO delivery to regulate CVD were reviewed, including the inhaled NO therapy to treat the pulmonary hypertension and COVID-19, stem cell therapy and NO-releasing platform to treat endothelial dysfunction and atherosclerosis.

show abstract

Computational analysis of nitric oxide biotransport in a microvessel influenced by red blood cells

Cited by 13 publications

References 50 publications

Delivery of Nitric Oxide in the Cardiovascular System: Implications for Clinical Diagnosis and Therapy

Delivery of Nitric Oxide in the Cardiovascular System: Implications for Clinical Diagnosis and Therapy

Endothelial Calcium Dynamics Elicited by ATP Release from Red Blood Cells

The Delivery of Nitric Oxide in the Cardiovascular System: Implication for Clinical Diagnosis and Therapy

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