Computational analysis of human and mouse CREB3L4 Protein

Abstract

CREB3L4 is a member of the CREB/ATF transcription factor family, characterized by their regulation of gene expression through the cAMP-responsive element. Previous studies identified this protein in mice and humans. Whereas CREB3L4 in mice (referred to as Tisp40) is found in the testes and functions in spermatogenesis, human CREB3L4 is primarily detected in the prostate and has been implicated in cancer. We conducted computational analyses to compare the structural homology between murine Tisp40α human CREB3L4. Our results reveal that the primary and secondary structures of the two proteins contain high similarity. Additionally, predicted helical transmembrane structure reveals that the proteins likely have similar structure and function. This study offers preliminary findings that support the translation of mouse Tisp40α findings into human models, based on structural homology.

Asymmetric dose–volume optimization with smoothness control for rotating‐shield brachytherapy

“…Based on the results shown in this study, substituting the previous IPSA method by ADOS for S-RSBT planning will reduce the optimization time cost and potentially reduce the delivery time while maintaining the D 90 values. For the previous study on D-RSBT planning with IPSA, 22 the same observation was held. The ADOS method may also find its applications in other IMBT methods such as dynamic modulated brachytherapy technique, 25 which has a similar mechanism as S-RSBT, given that the delivery plan can be induced from fluence maps.…”

“…As a vehicle to test ADOS, cervical cancer HDR-BT plans were used. As the delivery techniques of intensity-modulated BT (IMBT), two different RSBT techniques are used; singleshield RSBT (S-RSBT) 12,13 whose azimuthal emission angle is fixed during the delivery and dynamic-shield RSBT (D-RSBT) 22 whose azimuthal emission angle varies between 0 • and 180 • .…”

“…10,11,13,14,34,35 To get the full delivery efficiency curve of S-RSBT, the rapid emission angle selection algorithm is used to detect the most proper shield opening size for S-RSBT. 12 The current conceptual D-RSBT applicator design 22 features with two layers of partially opening shields, each of which covers 180 • azimuthal emission angle. Thus a dynamically varying emission window can be created during the delivery by rotating the inner and outer shields independently.…”

“…Thus a dynamically varying emission window can be created during the delivery by rotating the inner and outer shields independently. 22 In the optimal sequencing, the deliverable plan that most closely approximates the anchor plan under the delivery time constraint is efficiently computed.…”

Fast dose optimization for rotating shield brachytherapy

“…The radiation source is assumed to be partially shielded 50 kVp Xoft Axxent TM (Sunnyvale, CA, USA). To be consistent with previous work, it is assumed that the dose to the points blocked by the shield is 0, since the transmission rate from 50 kVp Xoft Axxent TM can be controlled to be less than 0.1% when using a 0.5 mm tungsten shield . Then, the radiation dose amount at the point , denoted by d i , can be quantified as a time‐weighted sum of all beamlets as follows: where t j , b is the dwell time of beamlet D i ( j , b ).…”