Computational analysis of catalase from different source organisms

Shahid, Muhammad; Amjad, Mahnoor; Ashraf, Umair; Jamal, Adil; Wattoo, Javed Iqbal

doi:10.30848/pjb2022-1(35)

Cited by 1 publication

(4 citation statements)

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“…This enzyme is common in aerobic organisms with a cytochrome system (with some exceptions) and has a major role in the prevention and repairing of cell damage by hydrogen peroxide excess 78–80 . Studies have shown that catalase can prevent skin ageing by reverting alterations related to MAP kinases 81 .…”

Section: Antioxidant Enzymesmentioning

confidence: 99%

“…78 This enzyme is common in aerobic organisms with a cytochrome system (with some exceptions) and has a major role in the prevention and repairing of cell damage by hydrogen peroxide excess. [78][79][80] Studies have shown that catalase can prevent skin ageing by reverting alterations related to MAP kinases. 81 Usually, it is isolated from bacteria and mammalian tissue and/or organs where it occurs at higher concentrations, such as the liver.…”

Section: Catalasementioning

confidence: 99%

“…81 Usually, it is isolated from bacteria and mammalian tissue and/or organs where it occurs at higher concentrations, such as the liver. 79,80,82 Catalase from Aspergillus niger, suggested for dermatological use, has a molecular weight of 385 kDa 83 and pI of 6.5. 84 Optimal temperature and pH are 60°C and 7.0, respectively, but the enzyme is stable at pHs from 4.0 to 8.3 and a temperature range from 20°C to 60°C.…”

Section: Catalasementioning

confidence: 99%

“…Studies have shown that catalase can prevent skin ageing by reverting alterations related to MAP kinases 81 . Usually, it is isolated from bacteria and mammalian tissue and/or organs where it occurs at higher concentrations, such as the liver 79,80,82 . Catalase from Aspergillus niger , suggested for dermatological use, has a molecular weight of 385 kDa 83 and pI of 6.5 84 .…”

Section: Antioxidant Enzymesmentioning

confidence: 99%

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Enzymes for dermatological use

Nascimento,

Torres‐Obreque,

Oliveira

et al. 2024

Experimental Dermatology

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Skin is the ultimate barrier between body and environment and prevents water loss and penetration of pathogens and toxins. Internal and external stressors, such as ultraviolet radiation (UVR), can damage skin integrity and lead to disorders. Therefore, skin health and skin ageing are important concerns and increased research from cosmetic and pharmaceutical sectors aims to improve skin conditions and provide new anti‐ageing treatments. Biomolecules, compared to low molecular weight drugs and cosmetic ingredients, can offer high levels of specificity. Topically applied enzymes have been investigated to treat the adverse effects of sunlight, pollution and other external agents. Enzymes, with a diverse range of targets, present potential for dermatological use such as antioxidant enzymes, proteases and repairing enzymes. In this review, we discuss enzymes for dermatological applications and the challenges associated in this growing field.

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Section: Antioxidant Enzymesmentioning

confidence: 99%