Generalizations of QCD in which the number of colors N is taken to infinity are characterized by profound mathematical properties, with far-reaching implications for fundamental problems and for phenomenological issues alike. In this contribution, after a brief introduction to the theoretical motivation for studying the large-N limit, the rôle of lattice computations in large-N gauge theories is discussed, and a selection of interesting results obtained in recent years is highlighted. Finally, some promising research directions for future studies are pointed out.