Compulsive water drinking in the setting of anticholinergic drug use: An unrecognized cause of chronic renal failure

Singh, Harmeet; Linas, Stuart L.

doi:10.1016/0272-6386(95)90593-6

Cited by 8 publications

(9 citation statements)

References 12 publications

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“…Prolonged polyuria as cause of ureter dilatation and bilateral non-obstructive hydronephrosis has been documented in patients with (nephrogenic) diabetes insipidus and psychogenic polydipsia [5–11]. This phenomenon was not only been observed in adult diabetes insipidus patients with polyuria since childhood, but also in adult patients with polyuria for only 3–5 years [11, 24].…”

Section: Discussionmentioning

confidence: 99%

“…Consequently this may result to higher pressure in the upper urinary tract which can cause ureter dilatation, hydronephrosis and ultimately renal function loss. This mechanism from polyuria to renal function loss has already been described several times in literature in patients with (nephrogenic) diabetes insipidus and psychogenic polydipsia [5–11]. To reduce the risk of these problems, patients with polyuria are therefore advised to void more frequently [5].…”

Section: Introductionmentioning

confidence: 98%

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Polyuria due to vasopressin V2 receptor antagonism is not associated with increased ureter diameter in ADPKD patients

et al. 2016

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Background Tolvaptan, a vasopressin V2 receptor antagonist, has been shown to reduce the rates of growth in total kidney volume (TKV) and renal function loss in ADPKD patients, but also leads to polyuria because of its aquaretic effect. Prolonged polyuria can result in ureter dilatation with consequently renal function loss. Therefore, we aimed to investigate the effect of tolvaptan-induced polyuria on ureter diameter in ADPKD patients. Methods 70 ADPKD patients were included (51 were randomized to tolvaptan and 19 to placebo). At baseline and after 3 years of treatment renal function was measured (mGFR) and MRI was performed to measure TKV and ureter diameter at the levels of renal pelvis and fifth lumbar vertebral body (L5). Results In these patients [65.7 % male, age 41 ± 9 years, mGFR 74 ± 27 mL/min/1.73 m2 and TKV 1.92 (1.27–2.67) L], no differences were found between tolvaptan and placebo-treated patients in 24-h urine volume at baseline (2.5 vs. 2.5 L, p = 0.8), nor in ureter diameter at renal pelvis and L5 (4.0 vs. 4.2 mm, p = 0.4 and 3.0 vs. 3.1 mm, p = 0.3). After 3 years of treatment 24-h urine volume was higher in tolvaptan-treated patients when compared to placebo (4.7 vs. 2.3 L, p < 0.001), but no differences were found in ureter diameter between both groups (renal pelvis: 4.2 vs. 4.4 mm, p = 0.4 and L5: 3.1 vs. 3.3 mm, p = 0.4). Conclusions Tolvaptan-induced polyuria did not lead to an increase in ureter diameter, suggesting that tolvaptan is a safe therapy from a urological point of view.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 98%

Polyuria due to vasopressin V2 receptor antagonism is not associated with increased ureter diameter in ADPKD patients

et al. 2016

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“…2 Since then, excessive urine flows and extensive dilatation of the urinary tract have been most frequently documented in young children with NDI, mostly a hereditary and X-linked disease, 3,4 and also in patients with CDI 5 and psychogenic polydipsia. 6 Apparently, persistent large urine volumes can lead to urinary bladder distension and hypertrophy with subsequent intramural obstruction of the distal ureteral segments. [3][4][5][6] With time, bladder contractility is compromised, ureteric peristalsis diminishes and large residual urine volumes worsens this functional obstructive uropathy.…”

Section: Introductionmentioning

confidence: 99%

“…6 Apparently, persistent large urine volumes can lead to urinary bladder distension and hypertrophy with subsequent intramural obstruction of the distal ureteral segments. [3][4][5][6] With time, bladder contractility is compromised, ureteric peristalsis diminishes and large residual urine volumes worsens this functional obstructive uropathy. 7 Excessive polyuric syndrome rarely gives rise to non-obstructive hydronephrosis, megaureter and neurogenic bladder.…”

Section: Introductionmentioning

confidence: 99%

A case of idiopathic diabetes insipidus presented with bilateral hydroureteronephrosis and neurogenic bladder: A pediatric case report and literature review

Yüksel

Kivrak

Şahin

et al. 2015

CUAJ

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Diabetes insipidus (DI) is a condition with heterogeneous clinical symptoms characterized by polyuria (urine output >4 mL/kg/hr) and polydipsia (water intake >2 L/m 2 /d). In children, acquired nephrogenic DI (NDI) is more common than central DI (CDI). Diagnosis is based on the presence of high plasma osmolality and low urinary osmolality with significant water diuresis. A water deprivation test with vasopressin challenge, though has limitations, is done to differentiate NDI from CDI and diagnose their incomplete forms. Neonates and young infants are better managed with hydration therapy alone. Older children with CDI are treated with desmopressin (1-deamino-8-D-arginine vasopressin, dDAVP). Its oral form is safe, highly effective and has dosing flexibility. We report a case of an 8-year-old male patient with CDI with severe bilateral non-obstructive hydronephrosis and megaureter. Dramatic clinical and radiological responses to dDAVP treatment were achieved and therapy reduced urine volume and led to marked radiological improvement in hydronephrosis.

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“…However, subjects at risks of rapid progressive hydronephrosis might prefer treatment with an aquaretic-drug and endure its side effects. Drugs capable of interfering with water hemostasis should be avoided as should anticholinergic medications with known undesired ability to limit bladder contractability [5].…”

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confidence: 99%

Bilateral (Acute) Hydronephrosis Mimicking Polycystic Renal Pathology

Moyosore¹

2017

MOJAP

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Complete or partial urethral obstruction results in progressive nephropathy in the subsequent calyxal and renal parenchymal damage. We report a case controlled giant hydronephrosis mimicking multiple polycystic kidney disease (PCKD). The fluid content in the collecting duct is about 1.4 liters.A 40 years old man with renal dimensions measuring RK: 118 x 62 mm; LK: 120 x 65 mm respectively reported for ultrasound examination. There was no evidence of malignancy after 8-month follow-up ultrasonography with drug treatment in the Internal Medical Unit; plus urologic evaluation and documentation. Expelled urinary volume via catheter was consistently measured.Although clinical symptoms and alternate list of diagnosis were suspected, it turned out to be a case of large hydronephrosis. Accurate diagnosis became challenging due to distortion of renal parenchyma and calyxal atrophy.Examining clinical presentations, real-time sonogram evaluation and treatment medication, it is concluded that ureteric calculus may be a main cause of bilateral hydronephrosis.

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Compulsive water drinking in the setting of anticholinergic drug use: An unrecognized cause of chronic renal failure

Cited by 8 publications

References 12 publications

Polyuria due to vasopressin V2 receptor antagonism is not associated with increased ureter diameter in ADPKD patients

Polyuria due to vasopressin V2 receptor antagonism is not associated with increased ureter diameter in ADPKD patients

A case of idiopathic diabetes insipidus presented with bilateral hydroureteronephrosis and neurogenic bladder: A pediatric case report and literature review

Bilateral (Acute) Hydronephrosis Mimicking Polycystic Renal Pathology

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