Compulsive eating and weight gain related to dopamine agonist use

Nirenberg, Melissa J.; Waters, Cheryl

doi:10.1002/mds.20757

Cited by 239 publications

(180 citation statements)

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“…The three patients include one treated with only ropinirole after 11 years of disease, 34 another treated with pramipexole in combination with selegiline 10 mg 7 and a third treated with pramipexole but lacking detailed clinical data. 9 The link between diverse drug profiles and punding is further strengthened by the marked discrepancy in prevalence among countries with different treatment practices; for instance, apomorphine is available in England (punding prevalence of 14%, 3 ) but not in Canada (prevalence of 1.4% 15 ).…”

Section: Methods and Review Criteriamentioning

confidence: 99%

“…These include pathological gambling, 6 hypersexuality, 7 compulsive shopping 8 and compulsive eating. 9 These disorders have been classified within overlapping psychiatric categories focusing on phenomenology, particularly among the impulse control disorders (ICDs). 10 These symptoms may be related primarily to PD pathology, and secondarily to compensatory mechanisms, treatments, unrelated comorbid disorders or underlying individual (hereditary, biological or psychological) vulnerabilities.…”

Section: Introductionmentioning

confidence: 99%

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Insights into pathophysiology of punding reveal possible treatment strategies

Fasano

Petrović²

2010

Mol Psychiatry

111

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Punding is a stereotyped behavior characterized by an intense fascination with a complex, excessive, nongoal oriented, repetitive activity. Men tend to repetitively tinker with technical equipment such as radio sets, clocks, watches and car engines, the parts of which may be analyzed, arranged, sorted and cataloged but rarely put back together. Women, in contrast, incessantly sort through their handbags, tidy continuously, brush their hair or polish their nails. Punders are normally aware of the inapposite and obtuse nature of the behavior; however, despite the consequent self-injury, they do not stop such behavior. The most common causes of punding are dopaminergic replacement therapy in patients affected by Parkinson's disease (PD) and cocaine and amphetamine use in addicts. The vast majority of information about punding comes from PD cases. A critical review of these cases shows that almost all afflicted patients (90%) were on treatment with drugs acting mainly on dopamine receptors D1 and D2, whereas only three cases were reported in association with selective D2 and D3 agonists. Epidemiological considerations and available data from animal models suggest that punding, drug-induced stereotypies, addiction and dyskinesias all share a common pathophysiological process. Punding may be related to plastic changes in the ventral and dorsal striatal structures, including the nucleus accumbens, and linked to psychomotor stimulation and reward mechanisms. Possible management guidelines are proposed.

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Section: Methods and Review Criteriamentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Insights into pathophysiology of punding reveal possible treatment strategies

Fasano

Petrović²

2010

Mol Psychiatry

111

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“…Other problems related to the use of dopamine agonists include weight gain (possibly related to overeating) 376 and edema (especially in the lower extremities). 377 In one study, leg swelling developed in 7% of pramipexole-treated patients within 1 year of treatment.…”

Section: Time (Months)mentioning

confidence: 99%

The scientific and clinical basis for the treatment of Parkinson disease (2009)

Olanow¹,

Stern²,

Sethi³

2009

Neurology

747

658

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Parkinson disease (PD) is an age-related neurodegenerative disorder that affects as many as 1-2% of persons aged 60 years and older. With the aging of the population, the frequency of PD is expected to increase dramatically in the coming decades. Current therapy is largely based on a dopamine replacement strategy, primarily using the dopamine precursor levodopa. However, chronic treatment is associated with the development of motor complications, and the disease is inexorably progressive. Further, advancing disease is associated with the emergence of features such as freezing, falling, and dementia which are not adequately controlled with dopaminergic therapies. Indeed, it is now appreciated that these nondopaminergic features are common and the major source of disability for patients with advanced disease. Many different therapeutic agents and treatment strategies have been evaluated over the past several years to try and address these unmet medical needs, and many promising approaches are currently being tested in the laboratory and in the clinic. As a result, there are now many new therapies and strategic approaches available for the treatment of the different stages of PD, with which the treating physician must be familiar in order to provide patients with optimal care. This monograph provides an overview of the management of PD patients, with an emphasis on pathophysiology, and the results of recent clinical trials. It is intended to provide physicians with an understanding of the different treatment options that are available for managing the different stages of the disease and the scientific rationale of the different approaches. 1 PD is the second most common neurodegenerative disorder, with an average age at onset of about 60 years. An estimated 5 million people throughout the world have PD, with 1 million individuals each in the United States and in Europe with the disorder. PD affects approximately 0.3% of the population and 1% to 2% of those older than 60 years.2 With the aging of the population and the substantial increase in the number of at-risk individuals older than 60 years, it is anticipated that the prevalence of PD will increase dramatically in the coming decades.

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“…Compulsive eating is the ingestion of a large amount of food in a short period of time and a sensation of lack of control over eating. Although compulsive eating may also be associated with dopaminergic drugs, most of these patients were already overweight previously to the disorder emergence 58 . The lack of insight by some patients and the fact that these patients usually feel guilty, and thus seldom report their symptoms, turn the identification of the ICDs very difficult.…”

Section: Impulse Control Disorders and Dopamine Dysregulation Syndromementioning

confidence: 99%

Neuropsychiatry of Parkinson's disease

Kümmer

Teixeira

2009

Arq. Neuro-Psiquiatr.

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-Parkinson's disease (PD) is traditionally regarded as a movement disorder. In recent years, however, non-motor symptoms have been considered significant factors of disability at all stages of the illness. Behavioral and psychological symptoms or neuropsychiatric syndromes associated with PD are frequent and may represent a challenge in the management of these patients. They include anxiety, depression, psychosis, sleep, sexual and impulse control disorders, apathy and cognitive dysfunction. Their pathogenesis in PD is complex, involving neurodegenerative, drug-related and psychological mechanisms. We will review the current knowledge of this growing field, also focusing on the management of theses syndromes.KEY WORDS: Parkinson's disease, neuropsychiatry, psychology, psychiatric disorders. Neuropsiquiatria da doença de ParkinsonResumo -A doença de Parkinson (DP) é tradicionalmente conhecida como um distúrbio do movimento. Entretanto, os sintomas não-motores têm sido considerados recentemente como fatores relevantes de incapacidade em todos os estágios da doença. Sintomas motores e comportamentais ou síndromes neuropsiquiátricas associadas à DP são frequentes e seu manejo pode se tornar um verdadeiro desafio. São comuns quadros de ansiedade, depressão, psicose, distúrbios do sono, transtornos do controle do impulso, apatia e disfunções cognitivas. A patogênese desses transtornos na DP é complexa, envolvendo mecanismos degenerativos, psicológicos e relacionados ao tratamento. Neste artigo, revisamos o estado do conhecimento desse campo de interesse crescente, também enfocando o manejo dessas síndromes. PALAVRAS-CHAVE: doença de Parkinson, neuropsiquiatria, psicologia, transtornos psiquiátricos.

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Compulsive eating and weight gain related to dopamine agonist use

Cited by 239 publications

References 32 publications

Insights into pathophysiology of punding reveal possible treatment strategies

Insights into pathophysiology of punding reveal possible treatment strategies

The scientific and clinical basis for the treatment of Parkinson disease (2009)

Neuropsychiatry of Parkinson's disease

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