Compromised White Matter Microstructural Integrity after Mountain Climbing: Evidence from Diffusion Tensor Imaging

Zhang, Haiyan; Lin, Jianzhong; Sun, Yingchun; Ye, Huiming; Wang, Xiaochuan; Yang, Tianhe; Jiang, Xing‐Tang; Zhang, Jiaxing

doi:10.1089/ham.2011.1073

Cited by 38 publications

(52 citation statements)

References 44 publications

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“…intracellular space of glia cells. Furthermore, these data identify similar locations of altered white matter water mobility as those observed previously in individuals after prolonged sojourns to high altitude 8,17,18 and in individuals native to high altitude. 19 It should be mentioned that by directly calculating T 2 and mean diffusivity, we avoided any potential confusion that 'T 2 -shine through' can cause on raw diffusion-weighted images.…”

Section: Discussionsupporting

confidence: 85%

Investigation of Whole-Brain White Matter Identifies Altered Water Mobility in the Pathogenesis of High-Altitude Headache

Lawley

Oliver

Mullins

et al. 2013

J Cereb Blood Flow Metab

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Elevated brain water is a common finding in individuals with severe forms of altitude illness. However, the location, nature, and a causative link between brain edema and symptoms of acute mountain sickness such as headache remains unknown. We examined indices of brain white matter water mobility in 13 participants after 2 and 10 hours in normoxia (21% O 2 ) and hypoxia (12% O 2 ) using magnetic resonance imaging. Using a whole-brain analysis (tract-based spatial statistics (TBSS)), mean diffusivity was reduced in the left posterior hemisphere after 2 hours and globally reduced throughout cerebral white matter by 10 hours in hypoxia. However, no changes in T 2 relaxation time (T 2 ) or fractional anisotropy were observed. The TBSS identified an association between changes in mean diffusivity, fractional anisotropy, and T 2 both supra and subtentorially after 2 and 10 hours, with headache score after 10 hours in hypoxia. Region of interest-based analyses generally confirmed these results. These data indicate that acute periods of hypoxemia cause a shift of water into the intracellular space within the cerebral white matter, whereas no evidence of brain edema (a volumetric enlargement) is identifiable. Furthermore, these changes in brain water mobility are related to the intensity of high-altitude headache.

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Section: Discussionsupporting

confidence: 85%

Investigation of Whole-Brain White Matter Identifies Altered Water Mobility in the Pathogenesis of High-Altitude Headache

Lawley

Oliver

Mullins

et al. 2013

J Cereb Blood Flow Metab

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“…Decreased FA values are associated with cytotoxic brain edema. Therefore, both vasogenic and cytotoxic brain edema might develop in hypoxic patients, which are consistent with the findings in populations that are exposed to high‐altitudes (Zhang et al., 2012a). …”

Section: Discussionmentioning

confidence: 99%

“…In addition, technically, ADC values can be directly obtained from ADC maps. Hypoxic brains have been shown to have both cytotoxic edema and vasogenic edema (Bailey et al., 2009; Zhang et al., 2012a), and hypoxia‐related DTI studies usually report both FA and ADC values. However, a previous study only calculated a decrease in FA on DTI maps in patients with COPD (Zhang et al., 2012b).…”

Section: Introductionmentioning

confidence: 99%

Vasogenic cerebral edema associated with the disability in activities of daily living in patients with chronic obstructive pulmonary disease

et al. 2018

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IntroductionThe aim of this study was to explore whether patients with chronic obstructive pulmonary disease (COPD) develop vasogenic cerebral edema, and whether this edema contributes to the COPD‐related disability.MethodsEighteen stable patients with COPD and 17 matched healthy volunteers were enrolled. Apparent diffusion coefficient (ADC) values were calculated by voxel‐based analysis using DTI‐Studio software based on diffusion tensor imaging. COPD‐related disability was calculated using activities of daily living (ADL) scale.ResultsIn patients with COPD, ADC increased in the white matter fiber tracts including the bilateral anterior cingulum and posterior corpus callosum and in the white matter fibers connecting the bilateral insular cortices, sub‐lobar cortices, and pars triangularis cortices and the left rectus and olfactory gyrus. However, after further controlling for cigarette smoking, the difference in ADC values in the posterior corpus callosum between groups disappeared. Patients with COPD had significantly higher scores in ADL than that in controls. Moreover, ADL scores were positively correlated with the increased regional ADC values.ConclusionVasogenic cerebral edema occurs in patients with COPD. Cigarette smoking may be a risk factor for COPD‐related vasogenic edema. Vasogenic cerebral edema may be related to the COPD‐related ADL impairment.

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“…Previous studies revealed that the corticospinal tract, as well as the corpus callosum (anterior and posterior body, splenium) (CC) are particularly susceptible to hypoxia (Zhang et al. 2012, 2013; Hunt et al. 2013).…”

Section: Introductionmentioning

confidence: 99%

Long‐term acclimatization to high‐altitude hypoxia modifies interhemispheric functional and structural connectivity in the adult brain

Chen

Li²,

Han³

et al. 2016

Brain and Behavior

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BackgroundStructural and functional networks can be reorganized to adjust to environmental pressures and physiologic changes in the adult brain, but such processes remain unclear in prolonged adaptation to high‐altitude (HA) hypoxia. This study aimed to characterize the interhemispheric functionally and structurally coupled modifications in the brains of adult HA immigrants.MethodsWe performed resting‐state functional magnetic resonance imaging (fMRI) and diffusion tensor imaging (DTI) in 16 adults who had immigrated to the Qinghai‐Tibet Plateau (2300–4400 m) for 2 years and in 16 age‐matched sea‐level (SL) controls. A recently validated approach of voxel‐mirrored homotopic connectivity (VMHC) was employed to examine the interhemispheric resting‐state functional connectivity. Areas showing changed VMHC in HA immigrants were selected as regions of interest for follow‐up DTI tractography analysis. The fiber parameters of fractional anisotropy and fiber length were obtained. Cognitive and physiological assessments were made and correlated with the resulting image metrics.ResultsCompared with SL controls, VMHC in the bilateral visual cortex was significantly increased in HA immigrants. The mean VMHC value extracted within the visual cortex was positively correlated with hemoglobin concentration. Moreover, the path length of the commissural fibers connecting homotopic visual areas was increased in HA immigrants, covarying positively with VMHC.ConclusionsThese observations are the first to demonstrate interhemispheric functional and structural connectivity resilience in the adult brain after prolonged HA acclimatization independent of inherited and developmental effects, and the coupled modifications in the bilateral visual cortex indicate important neural compensatory mechanisms underlying visual dysfunction in physiologically well‐acclimatized HA immigrants. The study of human central adaptation to extreme environments promotes the understanding of our brain's capacity for survival.

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Compromised White Matter Microstructural Integrity after Mountain Climbing: Evidence from Diffusion Tensor Imaging

Cited by 38 publications

References 44 publications

Investigation of Whole-Brain White Matter Identifies Altered Water Mobility in the Pathogenesis of High-Altitude Headache

Investigation of Whole-Brain White Matter Identifies Altered Water Mobility in the Pathogenesis of High-Altitude Headache

Vasogenic cerebral edema associated with the disability in activities of daily living in patients with chronic obstructive pulmonary disease

Long‐term acclimatization to high‐altitude hypoxia modifies interhemispheric functional and structural connectivity in the adult brain

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