Compromised Tissue Renewal in the Ageing Human Colonic Epithelium

Mitchell, Esther M.; Parris, Alyson; Bigwood, Loren; Scobioala-laker, Natalia; Reynolds, Amy; Lewis, Michael P.; Leung, Wing; Belshaw, Nigel J.; Johnson, Ian T.; Oue, Naohide; Yasui, Wataru; Beales, Ian; Jamieson, Crawford P.; Tremelling, Mark; Tighe, R; Prior, Alison; Williams, Mark R.

doi:10.1016/s0016-5085(11)61298-5

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“…In small intestine of aging mice, researchers observed a decrease in the number of crypts, an increase in crypt length and width, an increase in the number of cells in per crypt and an increase in villus length ( 14 ). In colon of aging human, researchers observed increased percentage of Ki67 positive cells and decreased number of cell divisions ( 15 ). Ki67 is a widely-used proliferation marker, whose effect on cell proliferation varies by cell type ( 16 ).…”

Section: The Impact Of Aging On the Intestinal Mucosal Barriermentioning

confidence: 99%

“…Researchers have assessed the number of ISCs during aging in different subjects using different ISC markers and derived different results. Researchers studied on aging human using the well-established ISC marker – Olfm4, and found an increase in the number of ISCs ( 15 ). A study on Drosophila found similar results – aging ISCs are activated in response to tissue damage or infection and then become highly proliferative ( 18 ).…”

Section: The Impact Of Aging On the Intestinal Mucosal Barriermentioning

confidence: 99%

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The impact of aging on intestinal mucosal immune function and clinical applications

et al. 2022

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Immune cells and immune molecules in the intestinal mucosa participate in innate and adaptive immunity to maintain local and systematic homeostasis. With aging, intestinal mucosal immune dysfunction will promote the emergence of age-associated diseases. Although there have been a number of studies on the impact of aging on systemic immunity, relatively fewer studies have been conducted on the impact of aging on the intestinal mucosal immune system. In this review, we will briefly introduce the impact of aging on the intestinal mucosal barrier, the impact of aging on intestinal immune cells as well as immune molecules, and the process of interaction between intestinal mucosal immunity and gut microbiota during aging. After that we will discuss potential strategies to slow down intestinal aging in the elderly.

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Section: The Impact Of Aging On the Intestinal Mucosal Barriermentioning

confidence: 99%

Section: The Impact Of Aging On the Intestinal Mucosal Barriermentioning

confidence: 99%