Compromised salivary parameters of children with juvenile idiopathic arthritis

Perestrelo, Bruna de Oliveira; Melo, Alice Rodrigues Feres de; Sant'Anna, Giselle Rodrigues de; Leite, Mariana Ferreira

doi:10.1016/j.oooo.2015.11.020

Cited by 7 publications

(6 citation statements)

References 33 publications

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“…Both a significantly higher OPO concentration [27, 28] and a lack of differences in the OPO activity in UWS in JIA children [21] were reported in the literature. A reduction in the salivary OPO activity was reported by de Oliviera Perestrelo et al [44]. Since the studies on the OPO activity concerned both unstimulated and stimulated saliva, they are difficult to compare.…”

Section: Discussionmentioning

confidence: 98%

“…In our studies, however, a significantly lower resting SF in the sample group of JIA patients did not co-occur either with a worse oral hygiene or with gingivitis compared to the control group. The findings of many studies differ markedly, some researchers have not found any differences in oral hygiene between the JIA patients and the control population [13, 18, 41, 43], whereas other studies have shown a worse oral hygiene in the course of JIA [14, 24, 25, 44, 45]. In contrast to the obtained results, also the co-occurrence of a higher accumulation of dental biofilm with a normal SF in JIA children compared to the control population has been described in the literature [24, 25].…”

Section: Discussionmentioning

confidence: 99%

“…In our research, similar to most studies presented in the literature, we concentrated on the analysis of UWS, which is a certain limitation of this study. The results of the study on stimulated saliva conducted by Melo et al and Perestrelo et al are also available [24, 44]. A full picture of changes occurring in saliva of JIA children could be given after the analysis of resting and stimulated saliva.…”

Section: Discussionmentioning

confidence: 99%

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Unstimulated salivary flow, pH, proteins and oral health in patients with Juvenile Idiopathic Arthritis

et al. 2017

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BackgroundThere have been inconsistent conclusions regarding salivary abnormalities and their effect on oral health of Juvenile Idiopathic Arthritis (JIA) patients. The purpose of the study was to evaluate the flow rate and selected biochemical parameters of unstimulated whole saliva in correlation to oral health in JIA children.MethodsThirty-four JIA patients and 34 age- and sex-matched controls not affected by JIA (C) were divided into two groups: with mixed and permanent dentition. DMFT/dmft, gingival and simplified oral hygiene indices were evaluated. Salivary flow rate, pH, lysozyme, lactoferrin, salivary protein concentrations and peroxidase activity were assessed.ResultsThe salivary flow rate was significantly lower in the total JIA group (0.41 ml/min) as compared with the C (0.51 ml/min) and in the permanent dentition of JIA children (0.43 ml/min) as compared with the C (0.61 ml/min). A significantly lower pH was observed in total (6.74), mixed (6.7) and permanent (6.76) dentition of JIA groups in comparison to the C (7.25, 7.21, 7.28 respectively). The specific activity of peroxidase was significantly higher in JIA patients (total 112.72 IU/l, mixed dentition 112.98 IU/l, permanent dentition 112.5 IU/l) than in the C group (total 70.03 IU/l, mixed dentition 71.83 IU/l, permanent dentition 68.61 IU/l). The lysozyme concentration in JIA patients (total and permanent dentition groups) was significantly higher than in the C group. There were no significant differences in lactoferrin and salivary protein concentrations. There were no statistically significant differences in oral status between JIA patients and C, respectively: DMFT = 5.71, dmft = 3.73, OHI-S = 0.95, GI = 0.25 and DMFT 5.71, dmft = 3.73, OHI-S = 0.85, GI = 0.24. The specific activity of peroxidase in the unstimulated whole saliva was inversely correlated with the GI index, whereas the salivary lysozyme concentration was inversely correlated with the dmft index in JIA patients.ConclusionIn the course of JIA occur a reduction of the resting salivary flow rate and a decrease of saliva pH. In spite of this, no differences in the clinical oral status between the JIA children population and the control group were found. The mobilisation of salivary peroxidase and lysozyme contributes to the maintenance of healthy oral tissues.

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Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Unstimulated salivary flow, pH, proteins and oral health in patients with Juvenile Idiopathic Arthritis

et al. 2017

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“…9 Yapılan araştırmalarda JIA görülen bireylerde, tamponlama kapasitesinde değişiklik, inorganik komponentlerde (kalsiyum, fosfat, potasyum, sodium, klorid vb) ve immün ve antimikrobiyal faktörlerde (IgA ve lizozim) azalma gibi tükürük içeriğinde değişiklikler meydana geldiği bildirilmiştir. [10][11][12] Ağız sağlığı, özellikle hastalık döneminde, kortikosteroidlerin ve anti-romatizmal ilaçların kullanımı ile bağışıklık sisteminin bastırıldığı durumlarda önem taşımaktadır. Kötü diş ve diş eti sağlığı, sistemik enfeksiyonlar için risk faktörleridir.…”

Section: Tepeklinikunclassified

“…22 JIA lı bireylerde tükürük parametrelerinin değerlendirildiği bir araştırmada, stimüle edilmiş tükürükteki antimikrobiyal, remineralizasyon ve lubrikant aktivitelerde azalma ve oral temizlik indeksi ile artmış biofilm akümülasyonu bildirilmiştir. 12 Başka bir araştırmada, yine sağlıklı bireyler ile karşılaştırıldığında JIA görülen bireylerde plak ile kaplı yüzeylerin oranı ile, sondalamada kanama ve sondalama derinliği değerlerinin yüksek olduğu gösterilmiştir. 20 Welbury ve ark.…”

Section: Tepeklinikunclassified

Oral health and temporomandibular joint involvement of patient with juvenile idiopathic arthritis

Giray¹,

Durmuş²,

Ertuğral³

et al. 2018

Yeditepe J Dent

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Bu çalışmanın amacı, İstanbul'daki büyük bir eğitim-araştırma hastanesine gelen ve JIA teşhisi konmuş çocuk hastaların ağız ve diş sağlığı durumlarını ve TME tutulumlarını değerlendirmek ve yaş ile cinsiyet eşleşmesi yapılmış sağlıklı çocuklar ile karşılaştırmaktır. Gereç ve Yöntem:Araştırmada, JIA teşhisi konmuş 35 çocuk hasta ile yaş ve cinsiyet eşleşmesi yapılmış 35 sağlıklı çocuk dahil edilmiştir. Yapılan muayenede demografik verilerin yanında çürük indeksi (DMFT ve dmft), TME bulguları (disfonksiyon, ağrı, ses, kısıtlı hareket), yüz karakteristikleri (mikrognati, retrognati, anterior open-bite) ve ilaç tedavileri kaydedilmiştir. Oral hijyen, 3 standart epidemiyolojik indeks (gingival index, plak indeksi ve oral temizlik indeksi) ile değerlendirilmiştir. Bulgular:Çalışma yaşları 6 ile 16 arasında değişmekte olan, 28'i (%40) erkek ve 42'si (%60) kız olmak üzere toplam 70 çocuk üzerinde yapılmıştır. Çocukların yaş ortalaması 10,28±3,49 yıldır. JIA grubu ile kontrol grubu arasında çürük açısından istatistiksel olarak anlamlı bir farklılık bulunmamaktadır. JIA grubunda kontrol grubuna göre yüksek oranda ağrı, ses ve kısıtlı hareket gözlenmiş, ancak aralarındaki fark istatistiksel olarak anlamlı bulunmamıştır. JIA grubunun gingival indeks düzeyi, kontrol grubundan istatistiksel olarak anlamlı düzeyde yüksek bulunmuştur. Sonuç:Bu sonuçlar, JIA' nın multidisipliner yönetiminde düzenli ağız-diş sağlığı hizmetinin rolünü vurgulamaktadır. Anahtar kelimeler: Jüvenil idiyopatik artrit, ağız-diş sağlığı, temporomandibular eklem SUMMARY Aim: The aim of this study was to evaluate the oral health conditions and TMJ involvement of the children diagnosed with JIA attending an education and research hospital in Istanbul and to compare them with age and gender matched healthy controls. Materials and Methods:The study included 35 children diagnosed with JIA and 35 age-and sex-matched healthy controls. In addition to demographic data, dental caries index (DMFT and DMFT), TMJ abnormalities (dysfunction, pain, voice, restricted movement), facial characteristics (micrognathia, retrognathia, anterior open bite) and used drug were recorded. Oral hygiene was assessed with 3 standard epidemiological indices (gingival index, plaque index and oral hygiene index). Results:The study was conducted on 70 children, aged between 6 to 16, 28 (%40) male and 42 (%60) female. The mean age of the children was 10.28 ± 3.49 years. There was no statistically significant difference between the JIA group and the control group in terms of caries. According to the control group, JIA group showed higher rates of pain, voice and restricted movement, but the differences between the groups were not found statistically significant. The gingival index level of the JIA group was found statistically significant-ÖZGÜN ARAŞTIRMA

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Review of paediatric gastrointestinal physiology relevant to the absorption of orally administered medicines

Wollmer

Ungell

Nicolas

et al. 2022

Advanced Drug Delivery Reviews

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Compromised salivary parameters of children with juvenile idiopathic arthritis

Cited by 7 publications

References 33 publications

Unstimulated salivary flow, pH, proteins and oral health in patients with Juvenile Idiopathic Arthritis

Unstimulated salivary flow, pH, proteins and oral health in patients with Juvenile Idiopathic Arthritis

Oral health and temporomandibular joint involvement of patient with juvenile idiopathic arthritis

Review of paediatric gastrointestinal physiology relevant to the absorption of orally administered medicines

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