Compromised Blood-Brain Barrier Junctions Enhance Melanoma Cell Intercalation and Extravasation
Federico Saltarin,
Adrian Wegmüller,
Leire Bejarano
et al.
Abstract:Melanoma frequently metastasises to the brain, and a detailed understanding of the molecular and cellular mechanisms underlying melanoma cell extravasation across the blood-brain barrier (BBB) is important for preventing brain metastasis formation. Making use of primary mouse brain microvascular endothelial cells (pMBMECs) as an in vitro BBB model, we imaged the interaction of melanoma cells into pMBMEC monolayers. We observed exclusive junctional intercalation of melanoma cells and confirmed that melanoma-ind… Show more
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