Comprometimento Cardíaco na Síndrome de Sweet: Um Achado Raro numa Doença Rara

Santos, Luís Graça; Kieselova, Katarina; Sá, Fernando Montenegro; Guardado, Joana

doi:10.36660/abc.20190249

Cited by 4 publications

(4 citation statements)

References 15 publications

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“…Over the years, the spectrum of the symptoms of SS occurred to be much wider—erythema nodosum‐like nodules on the limbs, oral ulcerations, arthralgia, myalgia (all present in the described case), erythematous, edematous plaques, pustules, bullae, as well as nausea, diarrhea, headache, and other neurological symptoms 6–11 . In rare cases of SS, myocardium may be involved 12 …”

Section: Discussionmentioning

confidence: 89%

“…[6][7][8][9][10][11] In rare cases of SS, myocardium may be involved. 12 Over the years, numerous new clinical variants were described: necrotizing SS, cellulitis-like SS, generalized pustular SS, subcutaneous SS as well as novel histological variants: histiocytoid-like, cryptococcoid, eosinophilic, lymphocytic and normolipemic xanthomized SS. 11 In 1999 the term "Neuro-Sweet Disease" was proposed for a variant with recurrent neurologic symptoms.…”

Section: Discussionmentioning

confidence: 99%

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Atypical presentation of Sweet syndrome with nodular erythema and oral ulcerations provoked by Ad26.COV2.SSARS‐CoV‐2 vaccination and review of literature

Bechtold

Owczarczyk‐Saczonek

2022

Dermatologic Therapy

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The aim of this article is to present the case of acute febrile neutrophilic dermatosis (Sweet syndrome-SS) after Ad26.COV2.S vaccination against SARS-CoV-2. To the best of our knowledge, this is the second case of SS provoked by this specific vaccine. What is more, the mildly symptomatic beginning of the disease, later followed by typical SS manifestation with a variety of symptoms including nodular erythema of the feet and oral ulcerations, made it very challenging to establish the diagnosis.The article focuses on the current literature on the acute febrile neutrophilic dermatosis, along with the coexistence with other neutrophilic dermatoses and anti-SARS-CoV-2 vaccinations as provoking factors. It emphasizes the necessity for sharing the knowledge and experience on the subject of SS's clinical manifestations and underlying causes to facilitate prompt diagnosis and introduction of appropriate treatment.

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Section: Discussionmentioning

confidence: 89%

Section: Discussionmentioning

confidence: 99%

Atypical presentation of Sweet syndrome with nodular erythema and oral ulcerations provoked by Ad26.COV2.SSARS‐CoV‐2 vaccination and review of literature

Bechtold

Owczarczyk‐Saczonek

2022

Dermatologic Therapy

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“…Fortunately, his chest pain never recurred after treatment of his leukemia. Cases in the literature regarding the combination of sweet syndrome and myocarditis are described in Table 2 [14][15][16][17]. All four patients were treated for their sweet syndrome with some form of steroid administration.…”

Section: Discussionmentioning

confidence: 99%

Myocarditis Concurrent with Sweet Syndrome: A Presentation of Acute Myeloid Leukemia

Burkeen

Pottinger

Iragavarapu

et al. 2021

Case Reports in Hematology

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Acute myeloid leukemia (AML) is the most common acute leukemia in American adults and portends a poor prognosis if untreated. Commonly, AML presents with symptoms related to concurrent leukopenia, anemia, or thrombocytopenia; however, due to its ability to affect many organ systems in the body, AML can have a highly varied clinical presentation. One such presentation is myocarditis, which is a rarely reported manifestation of AML. Myocarditis can have a varied clinical picture and often requires exclusion of other causes of cardiac dysfunction. Sweet syndrome, also known as acute febrile neutrophilic dermatosis, is another presentation of AML; however, it is more commonly associated with AML than cardiac involvement. Sweet syndrome can occur in patients with an already established malignancy or can occur de novo in a patient with previously undiagnosed cancer and, interestingly, can also be accompanied by extracutaneous manifestations, one of which is myocarditis. Herein, we report a case of a 45-year-old male with a history of obesity and depression who presented with chest pain, a tender and diffuse rash, and pancytopenia. Heart catheterization performed at outside institution was negative for coronary artery disease. Cardiac MRI images were compatible with myocarditis. Dermal biopsy of the rash was consistent with sweet syndrome. Peripheral blood flow cytometry and bone marrow biopsy confirmed the diagnosis of AML. He was treated with an induction chemotherapy regimen of 7 days of cytarabine and 3 days of daunorubicin with resolution of his chest pain and skin lesions. The patient had persistent leukemia cells on day 14 postinduction bone marrow biopsy and was treated with high-dose cytarabine reinduction treatment. Bone marrow biopsy with count recovery after reinduction therapy revealed complete response (CR).

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“…A Síndrome de Sweet é encontrada sobretudo em pessoas de 30 a 50 anos, apresentando uma incidência rara em crianças, sendo que o subtipo clássico e induzido por drogas acabam sendo mais comum no sexo feminino, já o subtipo associado a malignidade não possui predileção por nenhum gênero (Graça-Santos et al, 2020).…”

Section: Introductionunclassified

Síndrome de Sweet: relato de caso de um acontecimento raro

Leite

Santos

Silva

et al. 2021

RSD

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A síndrome de Sweet (SS) e uma condição inflamatória sistêmica rara, que se caracteriza-se pelo aparecimento súbito de placas e nódulos cutâneos eritêmo-edematoso, relacionados a sintomas sistêmicos e a infiltração de neutrófilos maduros a estudos histopatológicos. Atualmente a doença é classificada em três categorias: clássica (idiopática), associada à malignidade e induzida por drogas, sendo que a clássica constitui a maioria dos casos. Nesse contexto, apresentamos um caso de um homem de 72 anos com quadro típico da forma clássica de Síndrome de Sweet, onde apresentou regressão das lesões após 2 semanas de tratamento, sendo que nesses casos a regressão inicia-se 72 horas após o início da corticoterapia sistêmica. Apesar da Síndrome de Sweet ser uma doença rara, com o diagnóstico e a instauração terapêutica adequada e com a utilização da corticoterapia sistêmica, os resultados acabam sendo extremamente rápidos e favoráveis aos seus portadores. Assim sendo, o diagnóstico e a classificação da forma da Síndrome de Sweet concede um direcionamento terapêutico adequado, tendo em vista que nos casos em que são induzidos por drogas ou associados a neoplasias, só existem respostas terapêuticas satisfatórias e duradouras, quando se realiza o tratamento da doença de base e a suspensão da droga causadora, respectivamente.

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Comprometimento Cardíaco na Síndrome de Sweet: Um Achado Raro numa Doença Rara

Cited by 4 publications

References 15 publications

Atypical presentation of Sweet syndrome with nodular erythema and oral ulcerations provoked by Ad26.COV2.SSARS‐CoV‐2 vaccination and review of literature

Atypical presentation of Sweet syndrome with nodular erythema and oral ulcerations provoked by Ad26.COV2.SSARS‐CoV‐2 vaccination and review of literature

Myocarditis Concurrent with Sweet Syndrome: A Presentation of Acute Myeloid Leukemia

Síndrome de Sweet: relato de caso de um acontecimento raro

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