Compritol® 888 ATO: an innovative hot-melt coating agent for prolonged-release drug formulations

Barthélémy, Philippe; Laforêt, J.P; Farah, Nabil; Joachim, J

doi:10.1016/s0939-6411(98)00088-5

Cited by 94 publications

(39 citation statements)

References 4 publications

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“…Hot melt granulation method was used for compritol as it was insoluble polymer. The angle of repose values of granules were found to be xanthan gum (24)(25)(26)(27)(28)(29)(30)(31), hydroxy propyl methyl cellulose (22-30) and CD2 (21-28) which indicated that all the granules were free flowing and good enough for punching. The tablets were compressed using 8 mm or 10 mm punches depending on the total weight of the tablet.…”

Section: Resultsmentioning

confidence: 99%

Development and Evaluation of Diclofenac sodium Controlled Release Dosage Forms Using Natural, Hydrophilic and Hydrophobic Polymers and its Comparative Studies

Durga¹,

Duppala²,

Murthy³

2017

IJPER

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The aim of the present study is to develop the controlled release dosage form of diclofenac using hydrophilic polymers (xanthan gum from natural origin, hydroxy propyl methyl cellulose K 100M from semisynthetic origin) and hydrophobic polymer (compritol 888 ATO from synthetic origin). Diclofenac sodium matrix tablets were prepared by xanthan gum and hydroxy propyl methyl cellulose by wet granulation method. Hot melt granulation method was used for compritol as it was insoluble polymer. Fourier transform infrared spectroscopy (FTIR) analysis, differential scanning calorimetry (DSC) and X-Ray diffraction (XRD) studies indicated that there was no interaction between drug and polymers. Matrix tablets were formulated according to formulae and evaluated the suitability for controlled release systems for 24 h. Tablets prepared with xanthan gum, hydroxy propyl methyl cellulose and compritol matrix tablets showed zero order drug release. The hardness for all the formulations found to be in the range of 4-5 kg/cm 2 .The friability values of all formulations were found to be less than 1 %. The drug content of each individual preparation was found to be within the specified limits of the stated amount of diclofenac sodium. XGD4, HPD4 and CD2 formulations were considered as optimum formulations for oral controlled release of diclofenac sodium.

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Section: Resultsmentioning

confidence: 99%

Development and Evaluation of Diclofenac sodium Controlled Release Dosage Forms Using Natural, Hydrophilic and Hydrophobic Polymers and its Comparative Studies

Durga¹,

Duppala²,

Murthy³

2017

IJPER

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“…Moreover, studies that employed the procedure for preparing MRDDS were normally carried out in coating pan and fluid bed apparatus, which limits the technique as it involves sophistication. [10][11][12] The objective of the present investigation was to design MRDDS of R.HCL for the effective treatment of gastroesophageal diseases (GEDs) using HMC technique. Prolonged gastric retention of R.HCL in absorption window improves the bioavailability of the drug.…”

Section: Original Articlementioning

confidence: 99%

Untitled

Sudke¹

2017

AJP

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Aim: The objective of the present investigation involves the design of modified release multiunit drug delivery system for the effective treatment of gastroesophageal diseases (GEDs) using hot-melt coating (HMC) technique. Materials and Methods: Ranitidine hydrochloride (R.HCL) pellets were prepared using extrusion-spheronization and coated with different levels of hydrogenated castor oil (HCO) as HMC agent using pan pour method. To achieve the desirable release profile, R.HCL pellets were coated with a hybrid of HCO and sodium lauryl sulfate as a pore former. The pellets were evaluated for micromeritic properties, physicochemical properties, in vitro buoyancy study, dissolution study, and stability study. Optimized formulation was selected by comparison of the drug release profiles with theoretical release profile (TRP). Results: Formulation R6 with low floating lag time, floating time >12 h, and the drug release profile similar to TRP. Therefore, R6 was selected as optimized formulation and molded into unit dosage form by filling the pellets in hard gelatin capsules. The R6 formulation shows significant performance in vitro. Optimized formulation was showed no significant difference in their micromeritic properties, physicochemical properties, in vitro buoyancy, and dissolution release after storing under 40°C ± 2°C temperature and 75% ± 5% relative humidity for 3 months. Conclusion: This study confirms the modified release potential of HCO by successfully designing of modified multiparticulate drug delivery system of R.HCL using HMC technique. This drug delivery system may prove effective for the treatment of GEDs by sustained drug release in absorption window for prolong period.

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“…On the other hand, multiple-unit floating systems same as pellets and granules indicate lower dosedumping and inter-subject variability [5]. Compritol 888 ATO and gelucire have been used for sustained release dosage form [6]. Compritol or glyceryl behenate has hydrophobic property with low doi:10.5138/ijdd.2010.0975.0215.…”

Section: Introductionmentioning

confidence: 99%

Multiple unite sustained released floating of sodium diclofenac: Formulation and evaluation using factorial design.

Makhmalzadeh¹,

Jamei²,

Rahim³

et al. 2010

Int J Drug delivery

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The aim of this study was prepare and evaluate floating granules of sodium diclofenac with lipid excipient for prolonged gastric residence and reduced dose regimen. Floating granules prepared by extruder-spheronization technique. Compritol and gelucire as lipid excipient, HPMC as retardant and tween 80 as emulsifier were used. The effect of drug/lipid, drug/HPMC, drug amount, percentage of tween and type of lipid on floating ability, morphology and dissolution parameters were evaluated by factorial design. Results showed floating ability of granules was influenced by proportion of drug/lipid, drug/HPMC and percentage of tween. Floating property of Compritol was more than gelucire and provided good floating particles. Compritol granules provided suitable sustained release pattern in the manner that increase in D/L reduced D8 and MDT and increase in %T increased MDT. Higuchi model was the best fitted for dissolution data of granules prepared by Compritol and gelucire. In conclusion, Compritol provided more suitable floating ability and sustained release property.

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Compritol® 888 ATO: an innovative hot-melt coating agent for prolonged-release drug formulations

Cited by 94 publications

References 4 publications

Development and Evaluation of Diclofenac sodium Controlled Release Dosage Forms Using Natural, Hydrophilic and Hydrophobic Polymers and its Comparative Studies

Development and Evaluation of Diclofenac sodium Controlled Release Dosage Forms Using Natural, Hydrophilic and Hydrophobic Polymers and its Comparative Studies

Untitled

Multiple unite sustained released floating of sodium diclofenac: Formulation and evaluation using factorial design.

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