Compressive mechanical properties and biodegradability of porous poly(caprolactone)/chitosan scaffolds

Wan, Ying; Wu, Hua; Cao, Xiaoying; Dalai, Siqin

doi:10.1016/j.polymdegradstab.2008.08.001

Cited by 109 publications

(58 citation statements)

References 21 publications

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“…Nevertheless, the utility of PCL hinges within the containers demonstrate the applicability of constructing a self-disintegrating encapsulant. Studies have shown that PCL degradation can be carefully timed and controlled through its copolymerization with other biocompatible materials, such as collagen and chitosan (Tillman et al 2009;Wnek and Bowlin 2008;Wan et al 2008). This copolymerization strategy can be utilized to precisely engineer the kinetics of hinge degradation.…”

Section: Resultsmentioning

confidence: 99%

Self-folding micropatterned polymeric containers

Azam

Laflin

Jamal

et al. 2010

Biomed Microdevices

158

159

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We demonstrate self-folding of precisely patterned, optically transparent, all-polymeric containers and describe their utility in mammalian cell and microorganism encapsulation and culture. The polyhedral containers, with SU-8 faces and biodegradable polycaprolactone (PCL) hinges, spontaneously assembled on heating. Self-folding was driven by a minimization of surface area of the liquefying PCL hinges within lithographically patterned two-dimensional (2D) templates. The strategy allowed for the fabrication of containers with variable polyhedral shapes, sizes and precisely defined porosities in all three dimensions. We provide proof-of-concept for the use of these polymeric containers as encapsulants for beads, chemicals, mammalian cells and bacteria. We also compare accelerated hinge degradation rates in alkaline solutions of varying pH. These optically transparent containers resemble three-dimensional (3D) micro-Petri dishes and can be utilized to sustain, monitor and deliver living biological components.

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Section: Resultsmentioning

confidence: 99%

Self-folding micropatterned polymeric containers

Azam

Laflin

Jamal

et al. 2010

Biomed Microdevices

158

159

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“…Solvent casting/salt leaching [13], freeze-drying [14,15] and gas foaming [16] have been used to generate porosity in chitosan and composite mixtures of chitosan and other polymers. The disadvantages of these techniques include the use of toxic solvents, the removal of solvent by evaporation (which takes days or even weeks), labour-intensive processing, irregularly shaped pores, insufficient interconnectivity and the inability to culture cells throughout the hydrogel scaffold [17].…”

Section: Introductionmentioning

confidence: 99%

Fabrication of porous chitosan scaffolds for soft tissue engineering using dense gas CO2

et al. 2011

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“…Synthetic biodegradable polymers such as poly (3-caprolactone) (PCL) have superior mechanical properties compared to natural polymers and can be easily processed [4,5]. However, their applications in tissue engineering are limited because their intrinsic hydrophobicity and absence of cell-recognition sites hinder cellular penetration, adhesion, and growth into the porous structures [6,7]. Synthetic polymers are combined with natural polymers such as chitosan [6,7], collagen [8], and elastin [9] to overcome these drawbacks.…”

Section: Introductionmentioning

confidence: 99%