Compressional, mechanical and release properties of a novel gum in paracetamol tablet formulations

Abstract

The binding properties of Eucalyptus gum obtained from the incised trunk of Eucalyptus tereticornis, were evaluated in paracetamol tablet formulations, in comparison with that of Gelatin B.P. In so doing, the compression properties were analyzed using density measurements and the compression equations of Heckel, Kawakita and Gurham. In our work, the mechanical properties of the tablets were assessed using the crushing strength and friability of the tablets, while the drug release properties of the tablets were assessed using disintegration and dissolution times. The results of the study reveal that tablet formulations incorporating Eucalyptus gum as binder, exhibited faster onset and higher amount of plastic deformation during compression than those containing gelatin. What is more, the Gurnham equation could be used as a substitute for the Kawakita equation in describing the compression properties of pharmaceutical tablets. Furthermore, the crushing strength, disintegration and dissolution times of the tablets increased with binder concentration, while friability values decreased. We noted that no significant differences in properties exist between formulations derived from the two binders (p > 0.05) exist. While tablets incorporating gelatin exhibited higher values for mechanical properties, Eucalyptus gum tablets had better balance between mechanical and release properties - as seen from the CSFR/Dt values. Tablets of good mechanical and release properties were prepared using Eucalyptus gum as a binder, and, therefore, it could serve as an alternative binder in producing tablets with good mechanical strength and fast drug release.

Native and microwave-modified Terminalia mantaly gums as sustained-release and bioadhesive excipients in naproxen matrix tablet formulations

“…The gum was purified using previously described methods. 11,12 Briefly, the exudate was hydrated in a 0.5 : 95.5 (v/v) CHCl 3 /water mixture for five days with intermittent stirring; extraneous materials were removed by straining through a muslin cloth. Absolute ethanol was used to precipitate the gum from the solution.…”

“…CSFR has been described as a useful index for tablet quality. 12 Also, Bamiro et al reported that the higher the value of this index, the stronger the tablet. 24 The results obtained (Table 4) generally showed an increase in CSFR and hence, tablet strength, as binder and HPMC concentrations increased.…”

Impact of Thermal and Chemical Modifications on the Compression and Release Properties of Bambara Nut Starches in Directly Compressed Tablet Formulations

“…This means that the equation may be used to interpret the densification mechanisms of the ibuprofen tablet formulation . The Kawakita parameter P k , is an inverse measure of the total amount of plastic deformation in the compression process . A lower P k value is an indication of better or increased total plastic deformation …”

Optimized Delivery of Diclofenac Sodium Formulated in a Sustained Release Raphia Africana Hydrocolloid Matrix

“…The plant was authenticated in the herbarium facility of the Faculty of Pharmacy, University of Uyo, Nigeria and the voucher number of authentication is UUPH8 (eii). The gum was purified using an established procedure [10,15,16]. The raw Raffia gum was hydrated in 0.5: 95.5 (v/v) chloroform water mixture for 5 d with intermittent stirring; extraneous materials were removed by straining through a piece of calico cloth.…”