Compression Strength and Porosity of Single-Antibiotic Cement Vacuum-Mixed With Vancomycin

Evaluation of Elution and Mechanical Properties of High-Dose Antibiotic-Loaded Bone Cement: Comparative “In Vitro” Study of the Influence of Vancomycin and Cefazolin

“…It has however been demonstrated that this effect depends on antibiotic levels [47]. The maximum recommended concentration that does not compromise cement properties is not clearly defined yet, but most authors agree that when antibiotic concentration is low (between 5 and 10 wt.%), the properties may not be adversely affected [30,48].…”

“…The voids formed when antibiotic is released may increase fluid uptake and promote its diffusion [46], which explains the greater fluid uptake in the groups with cefazolin. Combining two different antibiotics in acrylic bone cement has an additive effect on the elution rates of both antibiotics, leading to a better antibiotic release [16,30,31,47], and may also provide an additional antimicrobial effect [33]. This effect may explain why this group had the highest mass gain.…”

How Long Does Antimycobacterial Antibiotic-loaded Bone Cement Have In Vitro Activity for Musculoskeletal Tuberculosis?

“…Antibiotic-loaded bone cement has been regarded as an important treatment modality for musculoskeletal tuberculosis, with published clinical evidence [1,32]. Since the availability of antibiotic-loaded bone cement varies depending on physical and chemical properties of the drug, it is necessary to search for a suitable drug that has proper physical properties after mixing [7,18,19]. In a previous study [20], we investigated the antibacterial activity and elusion characteristics of bone cement by incorporating isoniazid and rifampicin, which are the first-line antituberculosis drugs.…”

“…In future studies, the elution test should be designed to mimic the bone and joint environment. Second, a strength test of the antibiotic-loaded bone cement was not performed, even though this is an essential factor to consider when antibiotic-loaded bone cement is to be used in operations like total knee or hip replacement for tuberculosis arthritis [7,19,37,39], where the strength of the construct is important. Because the focus of our study Fig.…”

The Effects of Different Mixing Speeds on the Elution and Strength of High-Dose Antibiotic-Loaded Bone Cement Created With the Hand-Mixed Technique

“…In manual or hand mixing methods, the components are normally stirred in an open bowl with a spatula at 1 Hz for between 45 and 120 seconds [18]. The different techniques of bone cement preparation can affect the cement porosity and antibiotic elution [27,28]. Macaulay et al noted that the percent porosity that results from hand mixing bone cement is higher than that of bone cement produced via vacuum mixing [28].…”