Compression parameters of hexagonal boron nitride on direct compression mixture of microcrystalline cellulose and modified starch

Halaçoğlu, Mekin Doğa; Uğurlu, Timuçin

doi:10.3109/10837450.2014.920354

Cited by 3 publications

(2 citation statements)

References 22 publications

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“…Carr's Index value is in the range 5% -23%. If a CI value close to 5% indicates a very good low, and when a value approaching 23% indicates a poor low (Halaçoğlu and Uğurlu, 2015).…”

Section: Lubricantmentioning

confidence: 99%

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A review: Pharmaceutical excipients of solid dosage forms and characterizations

Sopyan

Santi

Berlian

et al. 2020

ijrps

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Excipients play an important role in formulating dosage forms. Exertion is empowered to help manufacture, provide, or collect dosage forms. Although considered pharmacological, excipients may consider a drug, due to chemical or physical interactions with the composition of the drug. Excipients have many functions in pharmaceutical dosage forms, including enhancing active ingredients in dosage forms, assisting active ingredients, disintegration, lubricants, binders, and suppliers. Each excipient has different characteristics. In this review, a library of studios is provided relating to the function, function, and content of solid excipients in a solid sedan. Various choices can be used on different compositions; resulting, this difference is also different. In this example, describe the types of excipients that can be used for various components in solid preparations that can be used in the formulation of solid preparations and select the right type of excipient according to the character of the desired solid preparation. In this review also presented a method, combining in and characterizing solid excipients to see the quality. The most commonly used methods for analysis of solid excipients are flow properties, compressibility index, Hausner index ratios, and angle of repose, while the instrumentation commonly used is Fourier transform infrared spectroscopy (FTIR), H and C-Nucleo magnetic resonance (H-CNMR), Scanning electron microscopy (SEM), Particle size analysis (PSA), X-ray diffraction (XRDP) and Differential scanning calorimeter (DSC).

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“…Carr's Index value is in the range 5% -23%. If a CI value close to 5% indicates a very good low, and when a value approaching 23% indicates a poor low (Halaçoğlu and Uğurlu, 2015).…”

Section: Lubricantmentioning

confidence: 99%

“…Based on the disintegration time and Heckel analysis, hexagonal boron nitride is better than magnesium stearate. Hexagonal boron nitride can also be used as a lubricant indirect or wet granulation (Halaçoğlu and Uğurlu, 2015).…”

Section: Lubricantmentioning

confidence: 99%

A review: Pharmaceutical excipients of solid dosage forms and characterizations

Sopyan

Santi

Berlian

et al. 2020

ijrps

View full text Add to dashboard Cite

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Effect of magnesium stearate solid lipid nanoparticles as a lubricant on the properties of tablets by direct compression

Martínez-Acevedo,

Job Galindo-Pérez,

Vidal-Romero

et al. 2023

European Journal of Pharmaceutics and Biopharmaceutics

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Effects of hexagonal boron nitride on dry compression mixture of Avicel DG and Starch 1500

Uğurlu¹,

Halaçoğlu²

2015

Pharmaceutical Development and Technology

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The objective of this study was to investigate the lubrication properties of hexagonal boron nitride (HBN) on a (1:1) binary mixture of Avicel DG and Starch 1500 after using the dry granulation-slugging method and compare it with conventional lubricants, such as magnesium stearate (MGST), glyceryl behenate (COMP) and stearic acid (STAC). MGST is one of the most commonly used lubricants in the pharmaceutical industry. However, it has several adverse effects on tablet properties. In our current study, we employed various methods to eradicate the work hardening phenomenon in dry granulation, and used HBN as a new lubricant to overcome the adverse effects of other lubricants on tablet properties. HBN was found to be as effective as MGST and did not show any significant adverse effects on the crushing strength or work hardening. From the scanning electron microscope (SEM) images, it was concluded that HBN distributed better than MGST. As well as showing better distribution, HBN's effect on disintegration was the least pronounced. Semi-quantitative weight percent distribution of B and N elements in the tablets was obtained using EDS (energy dispersive spectroscopy). Based on atomic force microscope (AFM) surface roughness images, formulations prepared with 1% HBN showed better plastic character than those prepared with MGST.

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Compression parameters of hexagonal boron nitride on direct compression mixture of microcrystalline cellulose and modified starch

Cited by 3 publications

References 22 publications

A review: Pharmaceutical excipients of solid dosage forms and characterizations

A review: Pharmaceutical excipients of solid dosage forms and characterizations

Effect of magnesium stearate solid lipid nanoparticles as a lubricant on the properties of tablets by direct compression

Effects of hexagonal boron nitride on dry compression mixture of Avicel DG and Starch 1500

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