Abstract:Indomethacin is a common nonsteroidal anti-inflammatory drug, but its glass transition behaviors remain ambiguous. Here we present a simple theoretical approach to investigate the molecular mobility of amorphous indomethacin under compression. In our model, the relaxation of a particle is governed by its nearest-neighbor interactions and long-range cooperative effects of fluid surroundings. On that basis, the temperature and pressure dependence of the structural relaxation time is deduced from the thermal expa… Show more
Set email alert for when this publication receives citations?
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.