Compression asymmetric static experimental model of degenerative disk diseases

Волков, А. В.; Goldshtein, D. V.; Shevelev, I. N.; Коновалов, Н. А.; Большакова, Г. Б.; Fathudinov, T. Kh.; Arutunov, N V; Zelenkov, P. V.

doi:10.1007/s10517-007-0270-0

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“…Питання чіткої межі між віковою нормою та патологічною дегенерацію міжхребцевих дисків, впливу ступеня дегенерації на клінічні прояви вважають дискутабельним [2, 9], з огляду на факти відсутності клінічних проявів при явних виражених дегенеративних змінах міжхребцевих дисків у осіб поважного віку [21] та вираженій клінічний симптоматиці при мінімальних дегенеративних змінах у осіб молодого віку [1,19]. Більшість авторів вважають, що патологія міжхребцевих дисків найчастіше призводить до порушень у функціональних сегментах [32], а такі широко вживані терміни як хондроз, остеохондроз, спондильоз, degenerative disc disease вкотре підкреслюють морфологічний субстрат патології хребта [15,31]. Незважаючи на актуальність проблеми патології хребтового стовпа як у світі так і в Україні, мала кількість наукових робіт вітчизняних вчених присвячена даній тематиці, зокрема виявленню патології на ранній стадії.…”

Section: вступunclassified

Morphometric parameters and indices of the lumbar intervertebral disks at girls and women

Danylevych¹,

Guminskyi²,

Hryhorieva³

et al. 2021

Rep. of Vinnytsia Nation. Med. Univ.

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Annotation. Individual variability of intervertebral discs is one of the factors that makes it difficult to recognize the early signs of their pathological changes before the onset of clinical manifestations. In the development of evidence-based medicine, it is important to use clear criteria for distinguishing between norm and pathology, taking into account individual variability. The “mathematical modeling” and a comprehensive approach to quantitative and qualitative assessment of intervertebral discs will help in the early detection of abnormalities, in the individualization of norm, as well as in modeling the parameters of the artificial intervertebral disc for reconstructive interventions. The analysis by methods of descriptive statistics and the correlation analysis for the purpose of further mathematical processing, selection of optimal parameters for mathematical modeling is carried out. Anthropometric characteristics (body length and body weight, mass-growth factor and mass-growth index) were determined in young women and women of the first period of adulthood (16-26 years), as in separate age groups and in the combined group. MRI of the lumbar spine was performed, followed by morphometry. Statistical analysis was performed in the license program “STATISTICA 6.1”. The mean values of the variation series, standard deviations, coefficients of variation and asymmetry, paired t-test, d-test of Kolmogorov-Smirnov type, Levene index were evaluated. It was determined that the sums of the transverse and sagittal dimensions and the sums of the three dimensions increase proportionally in the caudal direction, have a distribution of indicators as close as possible to normal, and their coefficients of variation are many times smaller than for cross-sectional areas and volumes. Indicators of the ratio of the sum of sagittal and transverse size and the sum of three sizes to the average height of the intervertebral discs have a variability of less than 10% and correspond to the characteristics of the general population. Body weight and body length have significantly higher correlation coefficients with the sums of sagittal and transverse dimensions, with the sums of three dimensions, and cross-sectional areas in comparison with the partial dimensions of the intervertebral discs.

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