Compressing the lumbar nerve root changes the frequency-associated cerebral amplitude of fluctuations in patients with low back/leg pain

Zhou, Fuqing; Zhao, Yanlin; Zhu, Li; Jiang, Jian; Huang, Muhua; Zhang, Yong; Zhuang, Yi; Gong, Honghan

doi:10.1038/s41598-019-38721-5

Cited by 6 publications

(6 citation statements)

References 53 publications

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“…Functional connectivity results suggest that, as pain becomes chronic (i.e., >1 y), the NAc subcircuitries fc show dynamic changes. We therefore studied power spectral density (PSD) (20, 21) because this approach uncovered meaningful differences among clinical populations (22) including chronic pain patients (23)(24)(25)(26)(27)(28)(29). We calculated PSD for different frequency bands defined in previous neurophysiological and fMRI studies (21,30,31) in bilateral NAc and compared among groups using a hypothesis-based approach.…”

Section: Sbpp and Sbpr Show Differences In Corticostriatal Functionalmentioning

confidence: 99%

Loss of nucleus accumbens low-frequency fluctuations is a signature of chronic pain

Makary

Polosecki

Cecchi

et al. 2020

Proc. Natl. Acad. Sci. U.S.A.

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Chronic pain is a highly prevalent disease with poorly understood pathophysiology. In particular, the brain mechanisms mediating the transition from acute to chronic pain remain largely unknown. Here, we identify a subcortical signature of back pain. Specifically, subacute back pain patients who are at risk for developing chronic pain exhibit a smaller nucleus accumbens volume, which persists in the chronic phase, compared to healthy controls. The smaller accumbens volume was also observed in a separate cohort of chronic low-back pain patients and was associated with dynamic changes in functional connectivity. At baseline, subacute back pain patients showed altered local nucleus accumbens connectivity between putative shell and core, irrespective of the risk of transition to chronic pain. At follow-up, connectivity changes were observed between nucleus accumbens and rostral anterior cingulate cortex in the patients with persistent pain. Analysis of the power spectral density of nucleus accumbens resting-state activity in the subacute and chronic back pain patients revealed loss of power in the slow-5 frequency band (0.01 to 0.027 Hz) which developed only in the chronic phase of pain. This loss of power was reproducible across two cohorts of chronic low-back pain patients obtained from different sites and accurately classified chronic low-back pain patients in two additional independent datasets. Our results provide evidence that lower nucleus accumbens volume confers risk for developing chronic pain and altered nucleus accumbens activity is a signature of the state of chronic pain.

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Section: Sbpp and Sbpr Show Differences In Corticostriatal Functionalmentioning

confidence: 99%

Loss of nucleus accumbens low-frequency fluctuations is a signature of chronic pain

Makary

Polosecki

Cecchi

et al. 2020

Proc. Natl. Acad. Sci. U.S.A.

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“…Physiological signals in the same brain network might compete or cooperate with each other in different frequency bands 36 . Our previous study showed that LBLP patients exhibit pain-related alterations in the cerebral amplitude of fluctuations and that regional homogeneity was frequency-dependent in several brain regions 5 , 18 . Thus, our study further proves that specific frequency ranges should be selected for the detection of pain-related intrinsic activity in LBLP patients.…”

Section: Discussionmentioning

confidence: 97%

“…BOLD signal fluctuations in different frequency bands may demonstrate different neurophysiological mechanisms 15 . Studies on fMRI generally consider the typical frequency band (0.01–0.1 Hz) to be of physiological significance 16 , 17 , but some studies of pain have found that the high frequency band (> 0.167 Hz) may also convey meaningful information 4 , 5 , 18 – 21 . Thus, the aim of this study was to determine whether the experience of persistent pain and paresthesia (numbness) influence the frequency-related cross- and within-network sFC and temporal variability in the dynamic pain connectome in LBLP patients.…”

Section: Introductionmentioning

confidence: 99%

Aberrant functional connectivity and temporal variability of the dynamic pain connectome in patients with low back related leg pain

Pei

Peng

Zhang

et al. 2022

Sci Rep

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Neuroimaging studies have suggested a link between the intensity of chronic low back pain intensity and structural and functional brain alterations. However, chronic pain results from the coordination and dynamics among several brain networks that comprise the dynamic pain connectome. Here, we use resting-state functional magnetic resonance imaging and measures of static (sFC) and dynamic functional connectivity (dFC) variability in the typical (0.01–0.1 Hz) and five specific (slow-6 to slow-2) frequency bands to test hypotheses regarding disruption in this variability in low back-related leg pain (LBLP) patients who experience chronic pain and numbness. Twenty-four LBLP patients and 23 healthy controls completed clinical assessments, and partial correlational analyses between altered sFC and dFC variability and clinical measures were conducted. We found a lower within-network sFC in the ascending nociceptive pathway (Asc) and a lower cross-network sFC between nodes of the salience network and the Asc in the typical frequency band. In the slow-5 frequency band, a lower within-network sFC was found in the Asc. Abnormal cross-network sFC was found between nodes of the salience network-Asc (slow-5 and slow-6) and the default mode network-Asc (slow-4 and slow-6). Furthermore, cross-network abnormalities in the typical and certain specific frequency bands were linked to clinical assessments. These findings indicate that frequency-related within- and cross-network communication among the nodes in the dynamic pain connectome is dysfunctional in LBLP patients and that selecting specific frequencies may be potentially useful for detecting LBLP-related brain activity.

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“…In patients with low back and leg pain, researchers have found a significant increase in ALFF in regions such as the inferior parietal lobule and medial prefrontal cortex ( Zhou et al, 2018 ; Zhou et al, 2019 ). Besides, the insula, amygdala, hippocampal/parahippocampal gyrus, and thalamus have been also found sensitive to pain intensity changes ( Zhang et al, 2019 ).…”

Section: Introductionmentioning

confidence: 99%

A spinal manipulative therapy altered brain activity in patients with lumbar disc herniation: A resting-state functional magnetic resonance imaging study

et al. 2022

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PurposeLumbar disc herniation (LDH) is one of the leading causes of low-back pain and results in a series of clinical symptoms, including pain, reflex loss, and muscle weakness. Spinal manipulative therapy (SMT) can relieve pain and promote internal and external stabilization of the lumbar spine. In this study, we investigated whether the brain alterations of LDH patients with SMT were frequency-dependent based on the calculation of Amplitude of Low-Frequency Fluctuations (ALFF) and fractional ALFF (fALFF). Further, we established a cohort of LDH patients to evaluate the contribution of SMT treatments to brain functional reorganization.MethodsA total of 55 participants, including 27 LDH patients and 28 health controls (HCs), were collected. All LDH patients underwent two fMRI scans (before SMT and after the sixth SMT session). To represent LDH-related brain oscillatory activities, we calculated the ALFF and fALFF in the conventional band (0.01–0.08 Hz), the slow-4 band (0.027–0.073 Hz), and the slow-5 band (0.01–0.027 Hz). Moreover, we extracted ALFF and fALFF values in clusters with significant differences to evaluate the SMT effect.ResultsCompared with HCs, the LDH patients before SMT (LDH-pre) exhibited increased fALFF in right lingual gyri in the conventional band, and showed increased fALFF in left Cerebelum_Crus1 in the slow-4 band. We further examined the abnormal brain activities changes before and after the SMT intervention. The ALFF and fALFF values of LDH-pre group were higher than those of the HCs and LDH-pos groups. After SMT, the increased ALFF and fALFF values were suppressed for patients in conventional band and slow-4 band.ConclusionThe present study characterized the altered regional patterns in spontaneous neural activity in patients with LDH. Meanwhile, SMT is an effective treatment of LDH, and we supposed that it might have been involved in modulating dysfunctional brain regions which are important for the processing of pain. The findings of the current study may provide new insights to understand pathological mechanism of LDH.

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Compressing the lumbar nerve root changes the frequency-associated cerebral amplitude of fluctuations in patients with low back/leg pain

Cited by 6 publications

References 53 publications

Loss of nucleus accumbens low-frequency fluctuations is a signature of chronic pain

Loss of nucleus accumbens low-frequency fluctuations is a signature of chronic pain

Aberrant functional connectivity and temporal variability of the dynamic pain connectome in patients with low back related leg pain

A spinal manipulative therapy altered brain activity in patients with lumbar disc herniation: A resting-state functional magnetic resonance imaging study

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