Compressed sensing time-resolved spectrometer for quantification of light absorbers in turbid media

Ioussoufovitch, Seva; Cohen, David J.; Milej, Daniel; Diop, Mamadou

doi:10.1364/boe.433427

Cited by 5 publications

(13 citation statements)

References 69 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The spectral resolution of the modified TR spectrometer-determined as the FWHM of the lamp's narrowest peak-was 5.8 nm; this was an improvement from the 6.1 nm resolution of the original spectrometer. 10 Figure 4C compares IRFs at 750 nm acquired by the original TR spectrometer 10 -which used a PMT detectorand the modified TR spectrometer; as expected, use of a hybrid detector eliminated the afterpulsing observed with the PMT.…”

Section: System Characterizationsupporting

confidence: 55%

“…We suspect that this causes the decrease in SSIM index, as a reduction in signal would impact the SNR of compressed data less due to the inherent suppression of highfrequency noise. 10 However, on average, SSIM index remains high, staying above 0.85 throughout the experiment. Given the small proportion of affected wavelengths, the impact of this effect on chromophore recovery is likely minimal.…”

Section: Discussionmentioning

confidence: 89%

“…This work presents a hyperspectral TR compressive sensing spectrometer with the spectral range and resolution to monitor changes in oxCCO and S t O 2 . After implementing key modifications to the original design of the TR compressive sensing spectrometer, 10 we evaluated the ability of the modified spectrometer to monitor oxCCO and S t O 2 in a homogeneous blood-yeast tissue-mimicking phantom using a 90% compression rate. There was strong agreement between DTOFs acquired with and without compression, and the differences between the ∆Hb, ∆HbO, and ∆oxCCO recovered from compressed and uncompressed data sets were negligible.…”

Section: Discussionmentioning

confidence: 99%

“…The system was spectrally calibrated using a mercury argon lamp (HG-1, Ocean Insight, USA) and the calibration procedure validated in Ref. 10. Thirteen peaks with known wavelengths (696.54, 706.72, 727.29, 738.40, 750.39, 763.51, 772.40, 800.62, 811.53, 826.45, 842.46, 851.59, and 870.87 nm) were identified in the measured spectrum.…”

Section: System Characterizationmentioning

confidence: 99%

See 3 more Smart Citations

Hyperspectral time-resolved compressive sensing spectroscopy for monitoring cytochrome-c-oxidase and blood oxygenation

Li¹,

Ioussoufovitch²,

Diop

2023

Optical Tomography and Spectroscopy of Tissue XV

View full text Add to dashboard Cite

Time-resolved (TR) near-infrared spectroscopy (NIRS) is a promising technique for neuromonitoring, but there are currently very few TR-NIRS devices with the spectral range and resolution needed for accurate monitoring of cerebral blood oxygenation (S t O 2 ) and metabolism (cytochrome-c-oxidase; oxCCO). Here we present a hyperspectral TR compressive sensing spectrometer with a wide spectral range, high spectral resolution, and no afterpulsing. A homogeneous blood-yeast phantom experiment was performed to evaluate the spectrometer's ability to monitor S t O 2 and oxCCO with and without compression. The effect of using a 90% compression rate on the recovered changes in deoxyhemoglobin (Hb), oxyhemoglobin (HbO), and oxCCO concentrations was investigated. No meaningful differences were found between concentration changes recovered from uncompressed and compressed data, with mean differences of 0.16 ± 0.20 µM , -0.25 ± 0.21 µM , and -0.04 ± 0.10 µM for Hb, HbO, and oxCCO, respectively. The results show that changes in oxCCO and S t O 2 can be reliably monitored with a high compression rate. Future work will compare the performance of the TR spectrometer with that of a continuous-wave spectrometer to assess accuracy and will investigate the sensitivity of the device to oxCCO and S t O 2 changes in the bottom compartment of a 2-layer tissue-mimicking phantom.

show abstract

Section: System Characterizationsupporting

confidence: 55%

Section: Discussionmentioning

confidence: 89%

Section: Discussionmentioning

confidence: 99%

Section: System Characterizationmentioning

confidence: 99%

See 2 more Smart Citations

Hyperspectral time-resolved compressive sensing spectroscopy for monitoring cytochrome-c-oxidase and blood oxygenation

Li¹,

Ioussoufovitch²,

Diop

2023

Optical Tomography and Spectroscopy of Tissue XV

View full text Add to dashboard Cite

show abstract

“…When analyzing trNIRS measurements, the IRF can be easily measured and its effects accounted for by convolving it with the analytical model. Note that for hyperspectral trNIRS measurements, the IRF of each wavelength must be measured as it has been shown that both the shape and temporal position of the IRF change with wavelength ( Ioussoufovitch et al, 2021 ).…”

Section: Discussionmentioning

confidence: 99%

Fast estimation of adult cerebral blood content and oxygenation with hyperspectral time-resolved near-infrared spectroscopy

Cohen

Li²,

Ioussoufovitch³

et al. 2023

Front. Neurosci.

Self Cite

View full text Add to dashboard Cite

Near-infrared spectroscopy (NIRS) can measure tissue blood content and oxygenation; however, its use for adult neuromonitoring is challenging due to significant contamination from their thick extracerebral layers (ECL; primarily scalp and skull). This report presents a fast method for accurate estimation of adult cerebral blood content and oxygenation from hyperspectral time resolved NIRS (trNIRS) data. A two-phase fitting method, based on a two-layer head model (ECL and brain), was developed. Phase 1 uses spectral constraints to accurately estimate the baseline blood content and oxygenation in both layers, which are then used by Phase 2 to correct for the ECL contamination of the late-arriving photons. The method was validated with in silico data from Monte-Carlo simulations of hyperspectral trNIRS in a realistic model of the adult head obtained from a high-resolution MRI. Phase 1 recovered cerebral blood oxygenation and total hemoglobin with an accuracy of 2.7 ± 2.5 and 2.8 ± 1.8%, respectively, with unknown ECL thickness, and 1.5 ± 1.4 and 1.7 ± 1.1% when the ECL thickness was known. Phase 2 recovered these parameters with an accuracy of 1.5 ± 1.5 and 3.1 ± 0.9%, respectively. Future work will include further validation in tissue-mimicking phantoms with various top layer thicknesses and in a pig model of the adult head before human applications.

show abstract

HyperTRCSS: A hyperspectral time-resolved compressive sensing spectrometer for depth-sensitive monitoring of cytochrome-c-oxidase and blood oxygenation

Li,

Ioussoufovitch,

Diop

2024

J. Biomed. Opt.

Self Cite

View full text Add to dashboard Cite

Hyperspectral time-resolved (TR) near-infrared spectroscopy offers the potential to monitor cytochrome-c-oxidase (oxCCO) and blood oxygenation in the adult brain with minimal scalp/skull contamination. We introduce a hyperspectral TR spectrometer that uses compressive sensing to minimize acquisition time without compromising spectral range or resolution and demonstrate oxCCO and blood oxygenation monitoring in deep tissue.Aim: Develop a hyperspectral TR compressive sensing spectrometer and use it to monitor oxCCO and blood oxygenation in deep tissue.Approach: Homogeneous tissue-mimicking phantom experiments were conducted to confirm the spectrometer's sensitivity to oxCCO and blood oxygenation. Twolayer phantoms were used to evaluate the spectrometer's sensitivity to oxCCO and blood oxygenation in the bottom layer through a 10 mm thick static top layer. Results:The spectrometer was sensitive to oxCCO and blood oxygenation changes in the bottom layer of the two-layer phantoms, as confirmed by concomitant measurements acquired directly from the bottom layer. Measures of oxCCO and blood oxygenation by the spectrometer were highly correlated with "gold standard" measures in the homogeneous and two-layer phantom experiments. Conclusions:The results show that the hyperspectral TR compressive sensing spectrometer is sensitive to changes in oxCCO and blood oxygenation in deep tissue through a thick static top layer.

show abstract

Compressed sensing time-resolved spectrometer for quantification of light absorbers in turbid media

Cited by 5 publications

References 69 publications

Hyperspectral time-resolved compressive sensing spectroscopy for monitoring cytochrome-c-oxidase and blood oxygenation

Hyperspectral time-resolved compressive sensing spectroscopy for monitoring cytochrome-c-oxidase and blood oxygenation

Fast estimation of adult cerebral blood content and oxygenation with hyperspectral time-resolved near-infrared spectroscopy

HyperTRCSS: A hyperspectral time-resolved compressive sensing spectrometer for depth-sensitive monitoring of cytochrome-c-oxidase and blood oxygenation

Contact Info

Product

Resources

About