An information-enhanced sparse binary matrix (IESBM) is proposed to improve the quality of the recovered ECG signal from compressed sensing. With the detection of the area of interest and the enhanced measurement model, the IESBM increases the information entropy of the compressed signal and preserves more information during compression; thus, it guarantees a high-quality recovery. The experimental results indicate that the proposed matrix is suitable for compressed sensing of the ECG signal with small distortions in both overall and the concerned diagnostic segments.Introduction: As a novel sampling paradigm, compressed sensing (CS) combines the sampling and compression into one step. It efficiently collects signals following the 'information rate' instead of the 'Nyquist rate'. This technology has attracted attention from both the industry world and the academic world, particularly in wireless body-area networks.Recently, the CS-enabled wireless electrocardiogram (ECG) nodes have been presented in many works [1][2][3][4]. The advantages of the CS-enabled wireless ECG node include low complexity, low cost, compactness and energy efficiency. There are three key aspects of CS-based ECG node: (i) the sparsity of the ECG signal, (ii) the measurement matrix and (iii) the recovery algorithm. Mamaghanian et al. [1] proposed the CS-based compression framework of wireless ECG transmission; Dixon et al. [2] discussed the CS system considerations for the wireless ECG sensor and Zhang et al. [3, 4], inspired from by correlation structure of the bio-signal, proposed a block sparse Bayesian learning (BSBL) algorithm for ECG CS recovery and obtained good results.Although there are extensive studies on the signal sparsity and the recovery algorithm, there is no report on the study of the measurement matrix for ECG compressed measurement. The signal quality of the recovered ECG, especially the QRS complex, still has room for improvement when some of the reported measurement matrices are used, such as the Bernoulli, 1-bit Toeplitz and 1-bit circulant matrices [2]. To achieve the smallest distortion for cardiovascular diagnosis has motivated us to develop a new measurement matrix for high-quality CS-based ECG application.This Letter presents an information-enhanced sparse binary matrix (IESBM) in CS for the ECG signal. To our knowledge, this is the first report on a custom-designed special measurement matrix for CS-based ECG application. With the detection of the area of interest (AI) and the enhanced measurement (EM) model, the matrix increases the information entropy of the compressed signal and preserves more information during compression, which guarantees high-quality recovery and small distortion of the overall signal as well as the concerned diagnostic ECG segments.