Abstract:Abstract-Screening for carriers of rare variants by resequencing is important for the identification of individuals carrying disease alleles. Rapid sequencing by new technologies enables lowcost resequencing of target regions, although it is still prohibitive to test more than a few individuals. Pooling designs can enable detection of carriers of rare alleles in groups of individuals in a more economical manner. Previous pooling strategies were shown only for a relatively low number of individuals in a pool, a… Show more
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