Comprehensive, untargeted, and qualitative RP-HPLC-ESI-QTOF/MS2 metabolite profiling of green asparagus (Asparagus officinalis)

Jiménez‐Sánchez, Cecilia; Lozano‐Sánchez, Jesús; Rodríguez‐Pérez, Celia; Segura‐Carretero, Antonio; Fernández‐Gutiérrez, Alberto

doi:10.1016/j.jfca.2015.11.004

Cited by 83 publications

(51 citation statements)

References 38 publications

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“…Under negative ion mode, organic acids often show diagnostic fragment ions by losing H 2 O (18 Da), CO (28 Da), CO 2 (44 Da), and HCOOH (46 Da). Peak 3 (195.0514, C 6 H 12 O 7 ) was identified as gluconic acid according to reference [ 28 ]. Peaks 5, 10, 18, and 49 were individually identified as malic acid (133.0148, C 4 H 6 O 5 ), citric acid (191.0200, C 6 H 8 O 7 ), p -coumaric acid (163.0404, C 9 H 8 O 3 ), and azelaic acid (187.0984, C 9 H 16 O 4 ) due to the diagnostic MS/MS fragment ions at 115.002 [M − H − H 2 O] − , 111.0083 [M − H − CO 2 − 2H 2 O] − , 119.0487 [M − H − CO 2 ] − , and 125.0970 [M − H − C 2 H 2 O 2 ] − , respectively [ 29 , 30 ].…”

Section: Resultsmentioning

confidence: 99%

Ultrasound-Assisted Extraction Optimization of α-Glucosidase Inhibitors from Ceratophyllum demersum L. and Identification of Phytochemical Profiling by HPLC-QTOF-MS/MS

Wang

et al. 2020

Molecules

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Ceratophyllum demersum L. (CDL) is a traditional Chinese herb to treat many diseases, but research on its anti-diabetic activity is not available. In this research, the α-glucosidase inhibitory ability and phytochemical constituents of CDL extract were firstly studied. Optimal ultrasound-assisted extraction conditions for α-glucosidase inhibitors (AGIs) were optimized by single factor experiment and response surface methodology (RSM), which was confirmed as 70% methanol, liquid-to-solid ratio of 43 (mL/g), extraction time of 54 min, ultrasonic power of 350 W, and extraction temperature of 40 °C. The lowest IC50 value for α-glucosidase inhibition was 0.15 mg dried material/mL (mg DM/mL), which was much lower than that of acarbose (IC50 value of 0.64 mg DM/mL). In total, 80 compounds including 8 organic acids, 11 phenolic acids, 25 flavonoids, 21 fatty acids, and 15 others were identified or tentatively identified from CDL extract by HPLC-QTOF-MS/MS analysis. The results suggested that CDL could be a potential source of α-glucosidase inhibitors. It can also provide useful phytochemical information for research into other bioactivities.

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Section: Resultsmentioning

confidence: 99%

Ultrasound-Assisted Extraction Optimization of α-Glucosidase Inhibitors from Ceratophyllum demersum L. and Identification of Phytochemical Profiling by HPLC-QTOF-MS/MS

Wang

et al. 2020

Molecules

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“…ESI‐MRM mode analysis by direct‐injection using predefined channels in the literature totaling 135 possible compounds isolated and identified from asparagus and the residues of asparagus with antioxidant activity (Fan, Yuan, Wang, Gao, & Huang, ; Jiménez‐Sánchez, Lozano‐Sánchez, Rodríguez‐Pérez, Segura‐Carretero, & Fernández‐Gutiérrez, ). This mode of the selection of compound‐specific ion‐pairs was able to identify 11 compounds, including hydroxy acids, cinnamic acids, benzoic acids, fatty acyls, organooxygen compounds, glycerol, and hexose derivatives (Table ), and was employed for analysis of organic compounds in complex matrices such as wine and plants (Delcambre & Saucier, ; Villagra, Santos, Vaz, Eberlin, & Laurie, ; Yue, Xu, Li, & Hou, ).…”

Section: Resultsmentioning

confidence: 99%

Effect of subcritical water processing on the extraction of compounds, composition, and functional properties of asparagus by‐product

Iwassa

Ribeiro

Meurer

et al. 2019

J Food Process Engineering

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The aim of this study was to submit the asparagus by‐product to the subcritical water treatment, evaluating the extraction of antioxidants compounds (AC) and total reducing sugars (TRS), as well as, the composition and technological properties of the residual material. The effects of temperature (100–160 °C) and pressure (100–200 bar) on extraction were evaluated, for total extraction time of 120 min. The results showed that the increase in temperature favored the removal of AC and this variable did not cause modification of most of the compounds identified by mass spectra analysis. The highest removal of AC was observed up to 30 min. The increase in temperature decreased the TRS content. The pressure did not affect the extraction of sugars and AC in the conditions evaluated. The treatment was efficient for the modification of the physico‐chemical composition and technological properties of residual material, reducing the TRS content and improving the ratio of soluble fiber to insoluble fiber. Practical applications Asparagus by‐product can be an interesting source of nutrients, like dietary fiber and antioxidant compounds. To maximize the antioxidant yield obtained from this by‐product, it can be used the subcritical water extraction (SWE) that is considered a green solvent. Besides this, the SWE promotes the concentration of dietary fibers of the treated material, due to the sugars removal, and improves the functional properties, which can facilitate the utilization of this material in the development of new food products.

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“…The consumption of asparagus has increased due to its being a good source of bioactive compounds [15][16][17]. The bioactive compounds such as flavonoid, lignin, and steroidal saponin have been found in asparagus [18][19].…”

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confidence: 99%

Genetic Diversity among Some Asparagus Species using rDNA ITS, cpDNA trnL Intron Sequence and Screening for Antioxidant Activity

Altıntaş¹,

Pakyürek²,

Şensoy³

et al. 2019

Pol. J. Environ. Stud.

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The genus Asparagus of the Asparagaceae family (formerly in Lilliceae) consist of three subgenera named Asparagus, Protasparagus, and Myrsiphyllum [1-2] and including around 100-300 species [3]. The species of subgenera Protasparagus and Myrsiphyllum comprise only hermaphroditic plants and mainly originated from Africa, while the species of Asparagus subgenera are dioecious and originated from minor Asia and Europe [4]. Although morphological traits are useful in identifying genotypes, the results are not exactly confidential because morphological traits can be influenced by environmental and growing conditions [5]. The restrictions of phenotype-based genetic markers gave rise to the progress of more general and

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Comprehensive, untargeted, and qualitative RP-HPLC-ESI-QTOF/MS2 metabolite profiling of green asparagus (Asparagus officinalis)

Cited by 83 publications

References 38 publications

Ultrasound-Assisted Extraction Optimization of α-Glucosidase Inhibitors from Ceratophyllum demersum L. and Identification of Phytochemical Profiling by HPLC-QTOF-MS/MS

Ultrasound-Assisted Extraction Optimization of α-Glucosidase Inhibitors from Ceratophyllum demersum L. and Identification of Phytochemical Profiling by HPLC-QTOF-MS/MS

Effect of subcritical water processing on the extraction of compounds, composition, and functional properties of asparagus by‐product

Genetic Diversity among Some Asparagus Species using rDNA ITS, cpDNA trnL Intron Sequence and Screening for Antioxidant Activity

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